用于下一代组织再生和医疗器械的新兴 4D 打印策略,Advanced Materials

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用于下一代组织再生和医疗器械的新兴 4D 打印策略
Advanced Materials ( IF 27.4 ) Pub Date : 2021-12-24 , DOI: 10.1002/adma.202109198
Yue Wang _{1,

2} , Haitao Cui ₃ , Timothy Esworthy ₃ , Deqing Mei _{1,

2} , Yancheng Wang _{1,

2} , Lijie Grace Zhang _{3,

4,

5,

6}

Affiliation

3D打印的飞速发展使生物医学工程领域取得了长足的进步。值得注意的是，4D 打印提供了一种潜在的策略，可以在组织支架内实现时间相关的物理变化，或复制天然组织的动态生物行为，以实现智能组织再生和医疗设备的制造。制造的刺激响应结构可以提供动态、可重新编程的变形或驱动，以模拟天然组织的复杂物理、生化和机械过程。尽管在开发用于各种生物医学应用的 4D 打印方法方面取得了显着进展，由于可打印智能材料的显着限制以及当前刺激源可能实现的响应的简单性，其在临床使用和组织工程目的中更广泛地采用变得复杂。在这篇评论中，通过讨论各种打印机制，重点介绍了 4D 驱动、构造结构设计和打印技术的智能墨水机制，重点介绍了 4D 打印领域的最新进展。然后总结了最近的 4D 打印研究，重点是组织/器官再生和医疗设备的应用。最后，还讨论了 4D 打印的当前挑战和未来前景。通过讨论实现的各种打印机制，重点介绍了 4D 驱动、构造结构设计和打印技术的智能墨水机制，重点介绍了 4D 打印领域的最新进展。然后总结了最近的 4D 打印研究，重点是组织/器官再生和医疗设备的应用。最后，还讨论了 4D 打印的当前挑战和未来前景。通过讨论实现的各种打印机制，重点介绍了 4D 驱动、构造结构设计和打印技术的智能墨水机制，重点介绍了 4D 打印领域的最新进展。然后总结了最近的 4D 打印研究，重点是组织/器官再生和医疗设备的应用。最后，还讨论了 4D 打印的当前挑战和未来前景。

"点击查看英文标题和摘要"

Emerging 4D Printing Strategies for Next-Generation Tissue Regeneration and Medical Devices

The rapid development of 3D printing has led to considerable progress in the field of biomedical engineering. Notably, 4D printing provides a potential strategy to achieve a time-dependent physical change within tissue scaffolds or replicate the dynamic biological behaviors of native tissues for smart tissue regeneration and the fabrication of medical devices. The fabricated stimulus-responsive structures can offer dynamic, reprogrammable deformation or actuation to mimic complex physical, biochemical, and mechanical processes of native tissues. Although there is notable progress made in the development of the 4D printing approach for various biomedical applications, its more broad-scale adoption for clinical use and tissue engineering purposes is complicated by a notable limitation of printable smart materials and the simplistic nature of achievable responses possible with current sources of stimulation. In this review, the recent progress made in the field of 4D printing by discussing the various printing mechanisms that are achieved with great emphasis on smart ink mechanisms of 4D actuation, construct structural design, and printing technologies, is highlighted. Recent 4D printing studies which focus on the applications of tissue/organ regeneration and medical devices are then summarized. Finally, the current challenges and future perspectives of 4D printing are also discussed.

更新日期：2021-12-24

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