4-Arm PEG-Functionalized Decellularized Pericardium for Effective Prevention of Postoperative Adhesion in Cardiac Surgery,ACS Biomaterials Science & Engineering

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4-Arm PEG-Functionalized Decellularized Pericardium for Effective Prevention of Postoperative Adhesion in Cardiac Surgery
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-12-22 , DOI: 10.1021/acsbiomaterials.1c00990
Yoshihide Hashimoto ₁ , Akitatsu Yamashita ₁ , Jun Negishi _{1,

2} , Tsuyoshi Kimura ₁ , Seiichi Funamoto ₁ , Akio Kishida ₁

Affiliation

Postoperative adhesions are a very common and serious complication in cardiac surgery, and the development of an effective anti-adhesion membrane showing resistance to the physical stimulus generated by the pulsation of the heart is desirable. In this study, an anti-adhesion material was developed through amine coupling between decellularized bovine pericardia (dBPCs) and 4-arm poly(ethylene glycol) succinimidyl glutarate (4-arm PEG-NHS) for the postoperative care of cardiac surgical patients. The efficacy of the 4-arm PEG-functionalized dBPCs in the prevention of adhesions after cardiac surgery was investigated in a rabbit heart adhesion model. The dBPCs meet the requirements for biocompatibility, flexibility, and sufficient suturable strength, and the 4-arm PEG moieties provide an anti-adhesion effect by the high excluded volume interactions of the PEG chains with proteins. The 4-arm PEG-functionalized dBPCs had a significantly greater anti-adhesion effect than the other materials tested and showed re-establishment of the mesothelial monolayer. These results suggested that the 4-arm PEG-functionalized dBPCs are a favorable material for an anti-adhesion membrane.

中文翻译：

用于有效预防心脏手术术后粘连的 4 臂 PEG 功能化去细胞心包

术后粘连是心脏手术中非常常见和严重的并发症，需要开发一种有效的抗粘连膜，以抵抗心脏搏动产生的物理刺激。在这项研究中，通过脱细胞牛心包（dBPCs）和四臂聚（乙二醇）琥珀酰亚胺戊二酸（四臂PEG-NHS）之间的胺偶联，开发了一种抗粘连材料，用于心脏手术患者的术后护理。在兔心脏粘连模型中研究了 4 臂 PEG 功能化 dBPC 在预防心脏手术后粘连方面的功效。dBPC 满足生物相容性、柔韧性和足够缝合强度的要求，并且 4 臂 PEG 部分通过 PEG 链与蛋白质的高排除体积相互作用提供抗粘附作用。与测试的其他材料相比，4 臂 PEG 功能化的 dBPC 具有显着更大的抗粘附作用，并显示间皮单层的重建。这些结果表明，4臂PEG功能化的dBPCs是抗粘连膜的有利材料。

更新日期：2022-01-10

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