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A mitochondrial and lysosomal targeted ratiometric probe for detecting intracellular H2S
Analytical Methods ( IF 2.7 ) Pub Date : 2021-12-13 , DOI: 10.1039/d1ay01783g Wenjie Liu 1 , Dandan Bu 1 , Hongyan Zhang 2 , Meng Zhang 1 , Haohui Ren 3 , Zhanxian Li 1 , Mingming Yu 1
Analytical Methods ( IF 2.7 ) Pub Date : 2021-12-13 , DOI: 10.1039/d1ay01783g Wenjie Liu 1 , Dandan Bu 1 , Hongyan Zhang 2 , Meng Zhang 1 , Haohui Ren 3 , Zhanxian Li 1 , Mingming Yu 1
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Based on coumarin and benzopyran derivatives, a dual-wavelength excitation ratiometric fluorescent probe, HABA, was prepared to detect H2S. The HABA probe showed good selectivity and anti-interference abilities during H2S detection. Fluorescence co-localization experiments showed that HABA had excellent localization abilities toward mitochondria and lysosomes. More importantly, HABA can not only detect exogenous H2S, but it can also detect endogenous H2S, indicating that HABA has high application potential and value in the biological field.
中文翻译：
用于检测细胞内 H2S 的线粒体和溶酶体靶向比率探针
基于香豆素和苯并吡喃衍生物，制备了双波长激发比率荧光探针HABA，用于检测H 2 S。HABA探针在H 2 S检测中表现出良好的选择性和抗干扰能力。荧光共定位实验表明HABA对线粒体和溶酶体具有优异的定位能力。更重要的是，HABA不仅可以检测外源性H 2 S，还可以检测内源性H 2 S，说明HABA在生物领域具有很高的应用潜力和价值。
更新日期：2021-12-23
中文翻译：
用于检测细胞内 H2S 的线粒体和溶酶体靶向比率探针
基于香豆素和苯并吡喃衍生物，制备了双波长激发比率荧光探针HABA，用于检测H 2 S。HABA探针在H 2 S检测中表现出良好的选择性和抗干扰能力。荧光共定位实验表明HABA对线粒体和溶酶体具有优异的定位能力。更重要的是，HABA不仅可以检测外源性H 2 S，还可以检测内源性H 2 S，说明HABA在生物领域具有很高的应用潜力和价值。
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