Amentoflavone is an active phenolic compound isolated from Selaginella tamariscina over 40 years. Amentoflavone has been extensively recorded as a molecule which displays multifunctional biological activities. Especially, amentoflavone involves in anti-cancer activity by mediating various signaling pathways such as extracellular signal-regulated kinase (ERK), nuclear factor kappa-B (NF-κB) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and emerges anti-SARS-CoV-2 effect via binding towards the main protease (Mpro/3CLpro), spike protein receptor binding domain (RBD) and RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. Therefore, amentoflavone is considered to be a promising therapeutic agent for clinical research. Considering the multifunction of amentoflavone, the current review comprehensively discuss the chemistry, the progress in its diverse biological activities, including anti-inflammatory, anti-oxidation, anti-microorganism, metabolism regulation, neuroprotection, radioprotection, musculoskeletal protection and antidepressant, specially the fascinating role against various types of cancers. In addition, the bioavailability and drug delivery of amentoflavone, the molecular mechanisms underlying the activities of amentoflavone, the molecular docking simulation of amentoflavone through in silico approach and anti-SARS-CoV-2 effect of amentoflavone are discussed.

Amentoflavone 是一种活性酚类化合物，分离自 卷柏超过40年。Amentoflavone 已被广泛记录为显示多功能生物活性的分子。特别是，阿蒙黄酮通过介导细胞外信号调节激酶 (ERK)、核因子 kappa-B (NF-κB) 和磷酸肌醇 3-激酶/蛋白激酶 B (PI3K/Akt) 等各种信号通路参与抗癌活性，并通过与 SARS-CoV-2 的主要蛋白酶 (Mpro/3CLpro)、刺突蛋白受体结合结构域 (RBD) 和 RNA 依赖性 RNA 聚合酶 (RdRp) 结合而产生抗 SARS-CoV-2 作用。因此，mentoflavone 被认为是一种有前途的临床研究治疗剂。鉴于 Amentoflavone 的多功能性，本综述全面讨论了其化学、其多种生物活性的进展，包括抗炎、抗氧化、抗微生物、代谢调节、神经保护、辐射保护、肌肉骨骼保护和抗抑郁，特别是对各种癌症的迷人作用。此外，阿蒙黄酮的生物利用度和药物递送，阿蒙黄酮活性的分子机制，阿蒙黄酮的分子对接模拟。计算机 讨论了 Amentoflavone 的方法和抗 SARS-CoV-2 作用。