ASCL1 and DLL3 expressions and their clinicopathological implications in surgically resected pure small cell lung cancer: A study of 247 cases from the National Cancer Center of China,Thoracic Cancer

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ASCL1 and DLL3 expressions and their clinicopathological implications in surgically resected pure small cell lung cancer: A study of 247 cases from the National Cancer Center of China
Thoracic Cancer ( IF 2.3 ) Pub Date : 2021-12-20 , DOI: 10.1111/1759-7714.14249
Chunfang Hu ₁ , Jiyan Dong ₁ , Li Liu ₁ , Jingbo Liu ₂ , Xujie Sun ₁ , Fei Teng ₃ , Xin Wang ₁ , Jianming Ying ₁ , Junling Li ₃ , Puyuan Xing ₃ , Lin Yang ₁

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Small cell lung cancer (SCLC) is one of the most aggressive malignancies characterized by neuroendocrine (NE) differentiation. The Delta-like protein 3 (DLL3), as a direct downstream target of ASCL1, is involved in NE differentiation and carcinogenesis of SCLC. This study aims to investigate the relationship between ASCL1 and DLL3 expressions and their clinicopathological implications in SCLC.

更新日期：2022-02-10

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