An efficient approach for the synthesis of novel series of 1,3-dihydrospiro[indene-2,6ʹ-[1,3]thiazine] derivatives,Monatshefte für Chemie - Chemical Monthly

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An efficient approach for the synthesis of novel series of 1,3-dihydrospiro[indene-2,6ʹ-[1,3]thiazine] derivatives
Monatshefte für Chemie - Chemical Monthly ( IF 1.7 ) Pub Date : 2021-12-19 , DOI: 10.1007/s00706-021-02878-5
Sara M. Mostafa ₁ , Ashraf A. Aly ₁ , Asmaa H. Mohamed ₁ , Stefan Bräse _{2,

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Affiliation

Facile synthesis of trimethoxyphenyl-1,3-dihydrospiro[indene-2,6ʹ-[1,3]thiazines was achieved during reaction of trimethoxyphenyl hydrazinecarbonothioyl hydrazinecarbothioamides with 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)propanedinitrile in dry THF as a solvent. The products were obtained in good to very good yields (78–90%). The structure assignment of all obtained products has been confirmed by ¹H and ¹³C NMR, IR, and mass spectra in addition to elemental analyses. The possible mechanism described the products formation was also discussed.

Graphical abstract

中文翻译：

一种合成新型系列 1,3-二氢螺[茚-2,6ʹ-[1,3]噻嗪]衍生物的有效方法

三甲氧基-1,3-二氢螺[茚-2,6'- [1,3]用2-（1,3-二氢-1,3-二氧代-2-三甲hydrazinecarbonothioyl hydrazinecarbothioamides的反应过程中实现的噻嗪类简便合成ħ - inden-2-ylidene)丙二腈在作为溶剂的干燥 THF 中。产品以良好到非常好的收率（78-90%）获得。除元素分析外，所有获得的产物的结构分配均已通过¹ H 和¹³ C NMR、IR 和质谱确认。还讨论了描述产物形成的可能机制。

图形概要

更新日期：2021-12-20

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