Nimbolide 抗癌治疗的分子靶点：最新综述,Journal of Environmental Pathology, Toxicology and Oncology

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Nimbolide 抗癌治疗的分子靶点：最新综述
Journal of Environmental Pathology, Toxicology and Oncology ( IF 2.1 ) Pub Date : 2022-01-01 , DOI: 10.1615/jenvironpatholtoxicoloncol.2021040263
Perumal Elumalai ₁ , Devaraj Ezhilarasan ₂ , Subramanian Raghunandhakumar ₃

Affiliation

癌症是世界范围内的主要死亡原因，发病率不断上升，被认为是主要的公共卫生问题。癌细胞向其他组织的远距离转移、高毒性和对化学疗法的耐药性需要新的治疗方法来治疗癌症。已经研究了来自药用植物的天然化合物在各种恶性肿瘤中的治疗用途。Nimbolide 是来自Azadirachta indica的活性主要化合物，这是一种亚洲传统药用植物，由于其抗氧化、抗炎、抗癌和抗菌特性，历史上被用作治疗多种疾病的药物。它是一种柠檬苦素三萜，在各种类型的癌症中具有有效的抗癌作用。据报道，通过改变各种分子信号通路来调节细胞增殖、细胞周期、细胞凋亡和转移，从而在肿瘤细胞中诱导多种细胞毒性作用。在本综述中，我们总结了所有的体外和体内研究报告了用于治疗不同类型癌细胞的 nimbolide 的分子靶点。我们分析了截至 2021 年 9 月关于 nimbolide 在各种恶性肿瘤中的作用及其分子作用机制的研究出版物。Nimbolide 靶向不同的信号通路，包括表皮生长因子 (EGF)、血管内皮生长因子 (VEGF)、胰岛素样生长因子 (IGF)、Wingless 和 INT-1 (Wnt)/β-连环蛋白、丝裂原活化蛋白激酶 (MAPK) /c-Jun N-末端激酶 (JNK)、磷酸肌醇 3-激酶 (PI3K)/AKT、肿瘤坏死因子-α (TNF-α)/核因子 kappa B (NF-κβ) 和死亡受体 5 (DR5)在几个癌细胞中。Nimbolide 的广泛可用性和无副作用，以及了解 nimbolide 作用的分子机制，

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Molecular Targets of Nimbolide for Anti-Cancer Therapy: An Updated Review

Cancer is a major cause of death worldwide with an increasing incidence rate and is considered a major public health problem. Distance metastasis to other tissues, high toxicity, and drug resistance of cancer cells to chemotherapy demand novel therapeutic approaches to treat cancer. Natural compounds from medicinal plants have been studied for therapeutic use in various malignancies. Nimbolide is an active principal compound from Azadirachta indica, which is an Asian traditional medicinal plant utilized historically as a remedy for a variety of diseases due to its antioxidant, anti-inflammatory, anti-cancer, and antimicrobial properties. It is a limonoid triterpene possessing potent anti-cancer effects in various types of cancers. It has been reported to induce multiple cytotoxic effects in tumor cells by modulating the cell proliferation, cell cycle, apoptosis, and metastasis by altering the various molecular signaling pathways. In the present review, we summarized all the in vitro and in vivo studies reporting the molecular targets of nimbolide for the therapeutic approaches in different types of cancer cells. We analyzed research publications up to September 2021 on the effect of nimbolide in various malignancies and the molecular mechanism of action. Nimbolide targets different signaling pathways including epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), insulin like growth factor (IGF), Wingless and INT-1 (Wnt)/β-catenin, mitogen-activated protein kinases (MAPK)/c-Jun N-terminal kinases (JNK), phosphoinositide 3-kinase (PI3K)/AKT, tumor necrosis factor-α (TNF-α)/nuclear factor kappa B (NF-κβ), and death receptor 5 (DR5) in several cancer cells. Nimbolide's widespread availability and absence of side effects, as well as understanding the molecular mechanism of nimbolide's action, will be useful to develop a therapeutic agent against cancer.

更新日期：2022-01-01

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