Raman spectra of Cinnarizine in the 35–3400 cm-¹ region were studied at high pressures up to 15.3 GPa, using a Diamond Anvil Cell. Broadening of bands is observed starting from ∼0.9 up to ∼11–12 GPa pressures as evidenced by the changes in the Raman spectra of some modes. Plots of frequency vs pressure of bands, show increase of frequency with pressure for most of the bands and the slopes, dω/dP, of some bands show clear changes around ∼2.7, ∼5, ∼7.5 ∼9 and ∼11–12 GPa indicating phase transformation caused by changes in structure and chemical bonds at these pressures. The present article describes high pressure effects on cinnarizine studied by Raman Spectroscopy and is supported by density function theoretical calculations.

使用金刚石砧座电池在高达 15.3 GPa 的高压下研究了 35-3400 cm- ¹区域内桂利嗪的拉曼光谱。一些模式的拉曼光谱的变化证明了从~0.9 到~11-12 GPa 压力范围内的谱带变宽。频段的频率与压力图显示大多数频段的频率随着压力的增加而增加，并且一些频段的斜率 dω/dP 在 ~2.7、~5、~7.5~9 和 ~11-12 GPa 附近显示出明显的变化表明在这些压力下结构和化学键的变化引起的相变。本文描述了拉曼光谱研究的桂利嗪的高压效应，并得到了密度函数理论计算的支持。