A novel aminoquinoline functionalized norbornene (1) and its ring-opening metathesis polymerization (ROMP) copolymer P1 have been designed and synthesized. The polymer probe P1 can self-assemble nano aggregation in aqueous solution. The fluorescent experiments revealed that both 1 and P1 show a ratiometric fluorescence response toward Zn²⁺ over other mental ions in Tris-HCl buffer solution, with the polymer probe P1 shows a better photostability and higher binding affinity than that of the small molecular probe 1. Furthermore, the in situ formed P1-Zn²⁺ ensemble was successfully used as the secondary sensor for ATP. P1 is also successfully used for monitoring intracellular Zn²⁺ and ATP in living cells.

设计并合成了一种新型氨基喹啉功能化降冰片烯 (1) 及其开环复分解聚合 (ROMP) 共聚物P1 。聚合物探针P1可以在水溶液中自组装纳米聚集体。荧光实验表明，在 Tris-HCl 缓冲溶液中， 1和P1对 Zn ²⁺比其他金属离子表现出比例荧光响应，聚合物探针P1比小分子探针1显示出更好的光稳定性和更高的结合亲和力. 此外，原位形成的P1-Zn ²⁺ensemble 成功地用作 ATP 的辅助传感器。P1还成功地用于监测活细胞中的细胞内 Zn ²⁺和 ATP。