Lipokines are bioactive compounds, derived from adipose tissue depots, that control several molecular signaling pathways. Recently, 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), an oxylipin, has gained prominence in the scientific literature. An increase in circulating 12,13-diHOME has been associated with improved metabolic health, and the action of this molecule appears to be mediated by brown adipose tissue (BAT). Scientific evidence indicates that the increase in serum levels of 12,13-diHOME caused by stimuli such as physical exercise and exposure to cold may favor the absorption of fatty acids by brown adipose tissue and stimulate the browning process in white adipose tissue (WAT). Thus, strategies capable of increasing 12,13-diHOME levels may be promising for the prevention and treatment of obesity and metabolic diseases. This review explores the relationship of 12,13-diHOME with brown adipose tissue and its role in the metabolic health context, as well as the signaling pathways involved between 12,13-diHOME and BAT.

脂质因子是生物活性化合物，源自脂肪组织库，可控制多种分子信号通路。最近，12,13-二羟基-9Z-十八烯酸（12,13-diHOME），一种oxylipin，在科学文献中获得了突出地位。循环 12,13-diHOME 的增加与代谢健康的改善有关，这种分子的作用似乎是由棕色脂肪组织 (BAT) 介导的。科学证据表明，由体育锻炼和暴露于寒冷等刺激引起的血清 12,13-diHOME 水平升高可能有利于棕色脂肪组织对脂肪酸的吸收，并刺激白色脂肪组织 (WAT) 的褐变过程。因此，能够提高 12,13-diHOME 水平的策略可能有望用于预防和治疗肥胖和代谢疾病。