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Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-Dimethylaminobenzohydrazide.
Acta chimica Slovenica Pub Date : 2021-09-01
Guo-Xu He , Ling-Wei Xue

A series of three new hydrazone compounds derived from the condensation reactions of 4-dimethylaminobenzohydrazide with 4-dimethylaminobenzaldehyde, 2-chloro-5-nitrobenzaldehyde and 3-methoxybenzaldehyde, respectively, were prepared. The compounds were characterized by elemental analysis, infrared and UV-vis spectra, HRMS, 1H NMR and 13C NMR spectra, and single crystal X-ray diffraction. Crystals of the compounds are stabilized by hydrogen bonds. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger and Candida albicans) activities by MTT method. The results indicated that compound 2 is an effective antibacterial material.

中文翻译:

4-二甲氨基苯甲酰肼衍生腙类化合物的合成、结构和抗菌活性。

分别由4-二甲氨基苯甲酰肼与4-二甲氨基苯甲醛、2-氯-5-硝基苯甲醛和3-甲氧基苯甲醛缩合反应制备了一系列三种新型腙化合物。通过元素分析、红外和紫外可见光谱、HRMS、1H NMR 和 13C NMR 光谱以及单晶 X 射线衍射对化合物进行了表征。化合物的晶体通过氢键稳定。通过MTT法测定化合物的抗菌(枯草芽孢杆菌、大肠杆菌、荧光假单胞菌和金黄色葡萄球菌)和抗真菌(黑曲霉和白色念珠菌)活性。结果表明化合物2是一种有效的抗菌材料。
更新日期:2021-09-01
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