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Multimicrochannel Microneedle Microporation Platform for Enhanced Intracellular Drug Delivery
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-12-13 , DOI: 10.1002/adfm.202109187 Long Lin 1, 2 , Yuqiong Wang 1 , Minkun Cai 3 , Xinran Jiang 1 , Yongyan Hu 4 , Zaizai Dong 1 , Dedong Yin 1 , Yilin Liu 5 , Shaohua Yang 6 , Zhiguang Liu 3 , Jian Zhuang 2 , Ye Xu 6 , Chuan Fei Guo 3 , Lingqian Chang 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-12-13 , DOI: 10.1002/adfm.202109187 Long Lin 1, 2 , Yuqiong Wang 1 , Minkun Cai 3 , Xinran Jiang 1 , Yongyan Hu 4 , Zaizai Dong 1 , Dedong Yin 1 , Yilin Liu 5 , Shaohua Yang 6 , Zhiguang Liu 3 , Jian Zhuang 2 , Ye Xu 6 , Chuan Fei Guo 3 , Lingqian Chang 1
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Common delivery routes for chemotherapeutics are based on circulation, which faces clinical limitations to local delivery efficiency, and the conflict between the dose for anticancer effect and the systemic toxicity. The recent advances in localized delivery strategies aim to improve drug accumulation at the target site or directly transport into cells. However, most are not equipped to provide additional momentum in the process of cargo release, propagation, and intracellular movement, which limit their locomotion that relies on passive diffusion. In this work, a multimicrochannel microneedle microporation (4M) platform that achieves high efficiency, safety, and uniformity for in vivo intracellular delivery is proposed. By high precision 3D printing, internal microchannels are implemented through the microneedle, which offer a concentrated, safe electric field that not only accelerates the movement of cargo into deep tissue under electrophoresis, but also triggers cell electroporation, achieving enhanced transport across cell membrane. The platform proves efficient for the delivery of chemotherapeutics in solid tumors in vitro and in vivo, with significantly enhanced anticancer effect and reduced systemic toxicity. The platform serves as a general-purpose delivery tool to emerging drugs in vivo.
中文翻译：
用于增强细胞内药物递送的多微通道微针微孔平台
化疗药物的常见给药途径是基于循环，其面临局部给药效率的临床局限性，以及抗癌作用剂量与全身毒性之间的冲突。局部递送策略的最新进展旨在改善药物在靶位点的积累或直接转运到细胞中。然而，大多数都没有装备在货物释放、传播和细胞内运动的过程中提供额外的动力，这限制了它们依赖于被动扩散的运动。在这项工作中，提出了一种多微通道微针微孔 (4M) 平台，该平台可实现高效、安全和均匀的体内细胞内递送。通过高精度 3D 打印，通过微针实现内部微通道，提供集中、安全电场，不仅可以加速电泳下货物向深层组织的移动，还可以触发细胞电穿孔，从而增强跨细胞膜的转运。该平台证明在体外和体内实体瘤中递送化疗药物是有效的，具有显着增强的抗癌作用和降低的全身毒性。该平台可作为体内新兴药物的通用交付工具。
更新日期：2021-12-13
中文翻译：
用于增强细胞内药物递送的多微通道微针微孔平台
化疗药物的常见给药途径是基于循环，其面临局部给药效率的临床局限性，以及抗癌作用剂量与全身毒性之间的冲突。局部递送策略的最新进展旨在改善药物在靶位点的积累或直接转运到细胞中。然而，大多数都没有装备在货物释放、传播和细胞内运动的过程中提供额外的动力，这限制了它们依赖于被动扩散的运动。在这项工作中，提出了一种多微通道微针微孔 (4M) 平台，该平台可实现高效、安全和均匀的体内细胞内递送。通过高精度 3D 打印，通过微针实现内部微通道，提供集中、安全电场，不仅可以加速电泳下货物向深层组织的移动，还可以触发细胞电穿孔，从而增强跨细胞膜的转运。该平台证明在体外和体内实体瘤中递送化疗药物是有效的，具有显着增强的抗癌作用和降低的全身毒性。该平台可作为体内新兴药物的通用交付工具。
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