In order to replace traditional wound treatments such as sutures, tissue adhesives with strong wet tissue adhesion and biocompatibility have attracted more attention to the applications of non-invasive wound closure. Herein, inspired by tunicate adhesive protein, a series of 2,3,4-trihydroxybenzaldehyde (TBA)-modified chitosan hydrogels (CS-TBA-Fe) were prepared by easily mixing the solutions of chitosan-FeCl₃ and TBA via the Schiff-base reaction and the coordination between Fe³⁺ and pyrogallol groups. The gelation time was greatly shortened to only several seconds after induced even trace Fe³⁺. The hydrogel (CS-TBA-Fe) exhibited ~12-fold enhanced wet tissue adhesion strength (60.3 kPa) over the commercial fibrin glue. Meanwhile, the hydrogel also showed robust adhesion to various substrates such as wood, PMMA, and aluminum. The swelling ratio and rheological property can be simply controlled by changing the concentrations of chitosan, TBA, and Fe³⁺. Moreover, the hydrogel displayed a rapid and highly efficient self-healing ability and an excellent antibacterial activity against E. coli. The overall results show that the CS-TBA-Fe hydrogel with enhanced wet adhesiveness will be a promising tissue adhesive material.

中文翻译：

---

具有自修复和抗菌特性的壳聚糖水凝胶粘合剂的简便制备

为了取代缝合等传统伤口处理方法，具有强湿组织粘附力和生物相容性的组织粘合剂越来越受到非侵入性伤口闭合应用的关注。在此，受被囊类动物粘附蛋白的启发，通过 Schiff -FeCl ₃和 TBA溶液轻松混合，制备了一系列 2,3,4-三羟基苯甲醛 (TBA) 修饰的壳聚糖水凝胶 (CS-TBA-Fe)。碱反应和 Fe ³⁺与连苯三酚基团之间的配位。甚至微量Fe ³⁺诱导后凝胶时间大大缩短至仅几秒. 与商业纤维蛋白胶相比，水凝胶 (CS-TBA-Fe) 的湿组织粘附强度 (60.3 kPa) 提高了约 12 倍。同时，水凝胶还对木材、PMMA 和铝等各种基材显示出强大的附着力。通过改变壳聚糖、TBA和Fe ³⁺的浓度可以简单地控制溶胀率和流变性能。此外，该水凝胶显示出快速高效的自愈能力和对大肠杆菌的优异抗菌活性。总体结果表明，具有增强湿粘合性的 CS-TBA-Fe 水凝胶将是一种很有前途的组织粘合材料。