Construction of Hydrodibenzo[b,d]furan Frameworks from Morita–Baylis–Hillman Carbonates of Isatins and o-Hydroxy Enones via Palladium and Brønsted Base Relay Catalysis,Organic Letters

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Construction of Hydrodibenzo[b,d]furan Frameworks from Morita–Baylis–Hillman Carbonates of Isatins and o-Hydroxy Enones via Palladium and Brønsted Base Relay Catalysis
Organic Letters ( IF 4.9 ) Pub Date : 2021-12-10 , DOI: 10.1021/acs.orglett.1c03689
Ze-Liang He ₁ , Peng Chen ₁ , Zhi-Chao Chen ₁ , Wei Du ₁ , Ying-Chun Chen _{1,

2}

Affiliation

A cascade assembly between isatin-derived Morita–Baylis–Hillman carbonates and o-hydroxybenzylideneacetones has been developed under the relay catalysis of Pd(PPh₃)₄ and DBU, affording a spectrum of 1,2,3,4-tetrahydrodibenzo[b,d]furan architectures incorporating a spirooxindole motif in moderate to good yields with excellent diastereoselectivity. The fused indole analogues were similarly furnished by employing the benzylideneacetones having an o-TsNH group.

中文翻译：

通过钯和布朗斯台德碱接力催化从 Morita-Baylis-Hillman 碳酸盐的靛红和邻羟基烯酮构建氢化二苯并[b,d]呋喃骨架

_{在 Pd(PPh 3} ) ₄和 DBU的中继催化下，靛红衍生的 Morita-Baylis-Hillman 碳酸盐和邻羟基苯亚甲基丙酮之间的级联组装得到了 1,2,3,4-四氢二苯并[ b , d ]呋喃结构包含螺氧吲哚基序，产率中等至良好，具有优异的非对映选择性。通过使用具有o -TsNH基团的亚苄基丙酮类似地提供稠合吲哚类似物。

更新日期：2022-01-14

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