通过两性离子特异性相互作用调节双两性离子嵌段共聚物聚集体,Langmuir

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通过两性离子特异性相互作用调节双两性离子嵌段共聚物聚集体
Langmuir ( IF 3.7 ) Pub Date : 2021-12-10 , DOI: 10.1021/acs.langmuir.1c02809
Akane Shimizu ₁ , Emi Hifumi ₂ , Ken Kojio _{3,

4} , Atsushi Takahara ₅ , Yuji Higaki ₆

Affiliation

可变形的双亲水嵌段共聚物组件作为生物相容的智能大分子系统是有效的。由聚（羧基甜菜碱甲基丙烯酸酯）（PCB2）和聚（磺基甜菜碱甲基丙烯酸酯）（PSB4）链（PCB2- b -PSB4）组成的双两性离子二嵌段共聚物自发组装的分子机制通过调节聚集体在对非洗涤剂两性离子的反应。具有高聚合度 PSB4 嵌段的 PCB2- b -PSB4 二嵌段共聚物通过“两性离子特异性”相互作用在无盐水中产生聚集体。PCB2- b-PSB4 聚集体通过添加非去污剂磺基甜菜碱 (SB4) 和羧基甜菜碱 (CB2) 分子解离，而聚集体对 SB4 和 CB2 表现出不同的聚集调节过程。具有来自 SB4 和 CB2 的不同电荷基团、甘氨酸和牛磺酸的两性离子几乎不会破坏 PCB2- b -PSB4 聚集体。PCB2- b -PSB4 聚合的 SB 调制效率与电荷间烃间隔长度 (CSL) 相关，而不是与 PSB 链中的 SB 的对称性有关。这些两性离子特异性调制行为基于两性离子的性质进行了合理化，包括部分电荷密度、偶极矩和取决于带电基团和 CSL 的疏水相互作用。

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Modulation of Double Zwitterionic Block Copolymer Aggregates by Zwitterion-Specific Interactions

Transformable double hydrophilic block copolymer assemblies are valid as a biocompatible smart macromolecular system. The molecular mechanisms in the spontaneous assembly of double zwitterionic diblock copolymers composed of a poly(carboxybetaine methacrylate) (PCB2) and a poly(sulfobetaine methacrylate) (PSB4) chains (PCB2-b-PSB4) were investigated by the modulation of the aggregates in response to nondetergent zwitterions. The PCB2-b-PSB4 diblock copolymers with a high degree of polymerization PSB4 block produced aggregates in salt-free water through “zwitterion-specific” interactions. The PCB2-b-PSB4 aggregates were dissociated by the addition of nondetergent sulfobetaine (SB4) and carboxybetaine (CB2) molecules, while the aggregates showed different aggregation modulation processes for SB4 and CB2. Zwitterions with different charged groups from SB4 and CB2, glycine and taurine, hardly disrupted the PCB2-b-PSB4 aggregates. The PCB2-b-PSB4 aggregate modulation efficiency of SBs associated with the intercharge hydrocarbon spacer length (CSL) rather than the symmetry with the SB in the PSB chain. These zwitterion-specific modulation behaviors were rationalized based on the nature of zwitterions including partial charge density, dipole moment, and hydrophobic interactions depending on the charged groups and CSL.

更新日期：2021-12-21

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