Biosynthesis of Gut-Microbiota-Derived Lantibiotics Reveals a Subgroup of S8 Family Proteases for Class III Leader Removal,Angewandte Chemie International Edition

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Biosynthesis of Gut-Microbiota-Derived Lantibiotics Reveals a Subgroup of S8 Family Proteases for Class III Leader Removal
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-12-10 , DOI: 10.1002/anie.202114414
Yingying Zhang ₁ , Zhilai Hong ₂ , Liang Zhou ₂ , Zhenkun Zhang ₂ , Ting Tang ₂ , Erpeng Guo ₂ , Jie Zheng ₁ , Ciji Wang ₁ , Lei Dai ₂ , Tong Si ₂ , Huan Wang ₁

Affiliation

A series of rat gut-microbiota-derived class III lanthipeptides with moderate antimicrobial activities were discovered by genome mining. The investigation of their biosynthesis revealed a subgroup of S8 family serine proteases for the removal of class III leader peptides.