Nickel-Catalyzed Stereo- and Enantioselective Cross-Coupling of gem-Difluoroalkenes with Carbon Electrophiles by C−F Bond Activation,Angewandte Chemie International Edition

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Nickel-Catalyzed Stereo- and Enantioselective Cross-Coupling of gem-Difluoroalkenes with Carbon Electrophiles by C−F Bond Activation
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-12-10 , DOI: 10.1002/anie.202113209
Ziqi Zhu ₁ , Lin Lin ₁ , Jieshuai Xiao ₁ , Zhuangzhi Shi _{1,

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Affiliation

A cross-electrophile coupling between gem-difluoroalkenes and benzyl electrophiles proceeds through nickel-catalyzed chelation-assisted C−F bond activation and shows excellent stereoselectivity and enantioselectivity.