Near-Infrared Light Triggered H2 Generation for Enhanced Photothermal/Photodynamic Therapy against Hypoxic Tumor,Advanced Healthcare Materials

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Near-Infrared Light Triggered H2 Generation for Enhanced Photothermal/Photodynamic Therapy against Hypoxic Tumor
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-12-08 , DOI: 10.1002/adhm.202101449
Haoying Ge ₁ , Jianjun Du _{1,

2} , Saran Long _{1,

2} , Xiang Xia ₁ , Jiazhu Zheng ₁ , Ning Xu ₁ , Qichao Yao _{1,

2} , Jiangli Fan _{1,

2} , Xiaojun Peng ₁

Affiliation

The principle of photochemical transformation has shown significant inspiration on phototherapy of solid tumors. However, both photodynamic therapy (PDT) and photothermal therapy (PTT) can induce stress response of tumor cells, which draw the attention in recent. Herein, an asymmetric and lollipop like nanostructure consisting of gold nanorod/titanium dioxide (l-TiO₂-GNR) is developed by controlling single head growth of titanium dioxide (TiO₂) on gold nanorods (GNR). Through the reasonable utilization of hot electrons of GNR by 808 nm light irradiation, l-TiO₂-GNR perform type I-PDT, mild PTT (48 °C), and H₂ therapy which is efficient for hypoxic tumors. In particular, H₂ can downregulate both triphosadenine and heat shock protein which are found to be main source of tumor stress response. l-TiO₂-GNR opens a new window for treatment of hypoxic tumor by the perfect synergy of type I-PDT, mild PTT, and H₂ therapy.

中文翻译：

近红外光触发 H2 生成，用于增强光热/光动力治疗缺氧肿瘤

光化学转化原理对实体瘤的光疗具有重要启示。然而，光动力疗法（PDT）和光热疗法（PTT）均能引起肿瘤细胞的应激反应，近年来备受关注。在此，通过控制二氧化钛（TiO ₂）在金纳米棒（GNR）上的单头生长，开发了一种由金纳米棒/二氧化钛（l -TiO _{2 -GNR）组成的不对称棒棒糖状纳米结构。}通过808nm光照射合理利用GNR的热电子，l -TiO ₂ -GNR进行I-PDT、轻度PTT（48℃）和H ₂治疗，对缺氧肿瘤有效。特别是，H₂可以下调三磷腺嘌呤和热休克蛋白，这些蛋白被发现是肿瘤应激反应的主要来源。l -TiO ₂ -GNR通过I型PDT、轻度PTT和H ₂治疗的完美协同，为缺氧性肿瘤的治疗打开了新的窗口。

更新日期：2022-02-10

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