ABSTRACT

Hydroxysafflor yellow A (HSYA) is a chalcone compound extracted from safflower. A growing number of discoveries suggest that HSYA has a better effect on metabolic diseases, including cancer, diabetes, and cardiovascular diseases, which has led to increasing attention on development and utilization in the pharmaceutical, food, and cosmetics industries. This review presents recent advances involved in the metabolic diseases and HSYA, and current evidence showing the importance of HSYA on metabolic signaling pathways, such as MAPK, PI3K/Akt et al. Although the research of HSYA metabolic regulation is only a beginning stage, it has already contributed to our current understanding of natural pigments. We also encourage further investigation to address the potential mechanism of HSYA under physiological and pathological conditions and further application in the pharmaceutical and food industries.

摘要

羟基红花黄 A (HSYA) 是从红花中提取的查耳酮化合物。越来越多的发现表明HSYA对癌症、糖尿病、心血管疾病等代谢性疾病具有较好的疗效，这使得HSYA在医药、食品、化妆品行业的开发利用日益受到关注。本综述介绍了代谢疾病和 HSYA 的最新进展，以及当前证据表明 HSYA 对代谢信号通路（如 MAPK、PI3K/Akt 等）的重要性。虽然HSYA代谢调控的研究还处于起步阶段，但它已经为我们目前对天然色素的认识做出了贡献。