Twelve novel hybridized 4-trifluoromethyl-(1,2,3-triazol-1-yl)quinolines (6–8), were synthesized at 77–95 % yields by a regioselective copper-catalysed azide-alkyne cycloaddition (CuAAC), and characterized by NMR spectroscopy, and single-crystal X-ray diffraction (SC-XRD) analysis. Subsequently, photophysical properties, BSA- and HSA-binding experiments, and molecular docking studies for the new series 6–8 were performed. These are discussed, and compared with similar compounds from recent research.

中文翻译：

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杂交 4-三氟甲基-(1,2,3-triazol-1-yl) 喹啉系统：合成、光物理学、选择性 DNA/HSA 生物相互作用和分子对接

通过区域选择性铜催化叠氮化物-炔烃环加成 (CuAAC) 以 77-95% 的产率合成了12种新型杂化 4-三氟甲基-(1,2,3-triazol-1-yl) 喹啉 ( 6-8 )，以及通过NMR光谱和单晶X射线衍射（SC-XRD）分析表征。随后，进行了新系列6-8的光物理特性、BSA 和 HSA 结合实验以及分子对接研究。对这些进行了讨论，并与最近研究中的类似化合物进行了比较。