Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Institute of Food Safety and Environment Monitoring, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, China.
Key Laboratory of Structure and Functional Regulation of Hybrid Materials, Ministry of Education, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, China.
Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, China.
A near-infrared photoacoustic (PA) probe Cypate-CBT was designed for specific imaging and real-time tracking of cathespin B (CTSB) activity in CTSB-overexpressing cells and tumors. After Cypate-CBT entered into CTSB-overexpressing cells, it underwent glutathione reduction and CTSB cleavage to generate cypate nanoparticles Cypate-CBT-NPs, which enhanced both the intensity and retention time of the PA signal in tumor sites.
中文翻译： 组织蛋白酶 B 引发的 Cypate 纳米颗粒形成用于肿瘤光声成像
近红外光声 (PA) 探针Cypate-CBT设计用于对 CTSB 过表达细胞和肿瘤中的组织蛋白酶 B (CTSB) 活性进行特异性成像和实时跟踪。 Cypate-CBT进入CTSB过表达细胞后，经过谷胱甘肽还原和CTSB裂解，生成cypate纳米颗粒Cypate-CBT-NPs ，增强了肿瘤部位PA信号的强度和保留时间。
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