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Continuous Miniaturized Draft Tube Baffle Crystallizer with Particle Screw for Supportive Suspension Discharge
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2021-12-06 , DOI: 10.1021/acs.iecr.1c03748 Mira Schmalenberg 1 , Tobias Krell 1 , Christopher Mathias 1 , Norbert Kockmann 1
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2021-12-06 , DOI: 10.1021/acs.iecr.1c03748 Mira Schmalenberg 1 , Tobias Krell 1 , Christopher Mathias 1 , Norbert Kockmann 1
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Continuous small-scale processes can enable faster process development and reduce time-to-market. However, for continuous crystallization, there are some hurdles, too, regarding suspension handling. Therefore, to overcome clogging issues concerning the product discharge, due to the smaller dimensions of a continuous draft tube baffle (DTB) crystallizer, a particle screw for supportive suspension discharge was developed and has been described throughout this work. First, the design of the particle screw is described. Furthermore, the particle screw is characterized, and cooling crystallization experiments (with l-alanine/water) are performed with a miniaturized (2 L) DTB. The presented particle screw showed negligible abrasion effects to the conveyed crystals. The investigations showed that the residence time of different particle sizes depends on the particle screw speed. Additionally, the continuous cooling crystallization experiments with 15 g min–1 confirm the supporting character of the suspension discharge by the particle screw. Thus, the newly developed particle screw for a supportive suspension discharge is well suited for continuous small-scale crystallization.
中文翻译：
连续微型导流管挡板结晶器，带颗粒螺杆，用于支持悬浮排放
连续的小规模工艺可以实现更快的工艺开发并缩短上市时间。然而，对于连续结晶，在悬浮液处理方面也存在一些障碍。因此，为了克服与产品排放有关的堵塞问题，由于连续导流管挡板 (DTB) 结晶器的尺寸较小，因此开发了一种用于支持悬浮液排放的颗粒螺杆，并在整个工作中进行了描述。首先介绍颗粒螺杆的设计。此外，对颗粒螺杆进行表征，并进行冷却结晶实验（用l-丙氨酸/水）使用小型化 (2 L) DTB 进行。所呈现的颗粒螺杆对输送的晶体的磨损影响可以忽略不计。研究表明，不同粒径的停留时间取决于颗粒螺杆速度。此外，15 g min –1的连续冷却结晶实验证实了颗粒螺杆对悬浮液排放的支持特性。因此，新开发的用于支持悬浮液排放的颗粒螺杆非常适合连续小规模结晶。
更新日期：2021-12-15
中文翻译：
连续微型导流管挡板结晶器，带颗粒螺杆，用于支持悬浮排放
连续的小规模工艺可以实现更快的工艺开发并缩短上市时间。然而，对于连续结晶，在悬浮液处理方面也存在一些障碍。因此，为了克服与产品排放有关的堵塞问题，由于连续导流管挡板 (DTB) 结晶器的尺寸较小，因此开发了一种用于支持悬浮液排放的颗粒螺杆，并在整个工作中进行了描述。首先介绍颗粒螺杆的设计。此外，对颗粒螺杆进行表征，并进行冷却结晶实验（用l-丙氨酸/水）使用小型化 (2 L) DTB 进行。所呈现的颗粒螺杆对输送的晶体的磨损影响可以忽略不计。研究表明，不同粒径的停留时间取决于颗粒螺杆速度。此外，15 g min –1的连续冷却结晶实验证实了颗粒螺杆对悬浮液排放的支持特性。因此，新开发的用于支持悬浮液排放的颗粒螺杆非常适合连续小规模结晶。
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