Abstract

Pyrrolones and pyrrolidinones are five-membered heterocycles and are versatile lead compounds for designing powerful bioactive agents. Pyrrolone and pyrrolidinone moieties are among the most essential heterocyclic pharmacophores inducing prominent pharmaceutical effects. Therefore, researchers paid attention to synthesize various pyrrolone and pyrrolidinone derivatives. Numerous methods for the synthesis of pyrrolones and pyrrolidinones offer a great scope in the field of medicinal chemistry. This attractive group of compounds has diverse biological activities like antimicrobial, anti-inflammatory, anticancer, antidepressant, anticonvulsant, etc. The purpose of this review is to classify broad information on the chemistry and pharma­ceutical effects of pyrrolones and pyrrolidinones to open a new perspective for future studies. It is clear that a wide spectrum of pyrrolones and pyrrolidinone derivatives have been synthesized and that most of them have various significant biological activities. Thus, these derivatives can be used for the future development of novel compounds active against different infections and diseases.

中文翻译：

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吡咯酮和吡咯烷酮衍生物作为有前景的支架的生物学重要性概述

摘要

吡咯酮和吡咯烷酮是五元杂环化合物，是用于设计强大生物活性剂的通用先导化合物。吡咯酮和吡咯烷酮部分是最重要的杂环药效团，可产生显着的药效。因此，研究人员重视合成各种吡咯酮和吡咯烷酮衍生物。许多合成吡咯酮和吡咯烷酮的方法为药物化学领域提供了广阔的空间。这组有吸引力的化合物具有多种生物活性，如抗菌、抗炎、抗癌、抗抑郁、抗惊厥等。 本综述的目的是对吡咯酮和吡咯烷酮的化学和药物作用的广泛信息进行分类，为未来的研究。很明显，已经合成了广谱的吡咯酮和吡咯烷酮衍生物，并且它们中的大多数具有各种重要的生物活性。因此，这些衍生物可用于未来开发对不同感染和疾病具有活性的新型化合物。