New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis,Chemical Communications

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New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis
Chemical Communications ( IF 4.3 ) Pub Date : 2021-11-26 , DOI: 10.1039/d1cc05700f
Wei Sun ₁ , William A T Raimbach ₁ , Luke D Elliott ₂ , Kevin I Booker-Milburn ₂ , David C Harrowven ₁

Affiliation

An oxidative photocyclisation of N-arylenaminones to indoles is described, that mirrors the Fischer indole synthesis but uses anilines in place of arylhydrazines. Its value is exemplified with new approaches to the WHO-listed APIs ondansetron and alosetron.

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