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A hydrophobic antifouling surface coating on bioprosthetic heart valves for enhanced antithrombogenicity
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.2 ) Pub Date : 2021-12-01 , DOI: 10.1002/jbm.b.34982
Meiling Li 1 , Cheng Zheng 1 , Shumang Zhang 1 , Binggang Wu 1 , Kailei Ding 1 , Xueyu Huang 1 , Yang Lei 1 , Yunbing Wang 1
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.2 ) Pub Date : 2021-12-01 , DOI: 10.1002/jbm.b.34982
Meiling Li 1 , Cheng Zheng 1 , Shumang Zhang 1 , Binggang Wu 1 , Kailei Ding 1 , Xueyu Huang 1 , Yang Lei 1 , Yunbing Wang 1
Affiliation
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Thrombosis is an important factor that causes the failure of artificial biological valves in addition to calcification and immune rejection. A hydrophobic antifouling surface can improve blood compatibility by reducing the absorption of protein. In this study, porcine pericardium was cross-linked with glycidyl methacrylate, and carbon–carbon double bonds were introduced. Then, fluoride monomer was added so that the pericardial surface would become hydrophobic and antifouling. Fluoride modification changed the hydrophilicity of the pericardium surface, and the surface water contact angle increased from 84° to 143°. Compared with unmodified pericardium, the adsorption of bovine serum albumin and fibrinogen decreased by 93.1% and 85%, respectively, and the anti-thrombogenicity was greatly enhanced.
中文翻译:
生物人工心脏瓣膜上的疏水防污表面涂层可增强抗血栓形成能力
除了钙化和免疫排斥反应外,血栓形成是导致人工生物瓣膜失效的重要因素。疏水性防污表面可以通过减少蛋白质的吸收来提高血液相容性。本研究将猪心包与甲基丙烯酸缩水甘油酯交联,并引入碳-碳双键。然后,添加氟化物单体,使心包表面变得疏水和防污。氟改性改变了心包表面的亲水性,表面水接触角从84°增加到143°。与未经修饰的心包相比,牛血清白蛋白和纤维蛋白原的吸附量分别降低了93.1%和85%,抗血栓能力大大增强。
更新日期:2021-12-01
中文翻译:
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生物人工心脏瓣膜上的疏水防污表面涂层可增强抗血栓形成能力
除了钙化和免疫排斥反应外,血栓形成是导致人工生物瓣膜失效的重要因素。疏水性防污表面可以通过减少蛋白质的吸收来提高血液相容性。本研究将猪心包与甲基丙烯酸缩水甘油酯交联,并引入碳-碳双键。然后,添加氟化物单体,使心包表面变得疏水和防污。氟改性改变了心包表面的亲水性,表面水接触角从84°增加到143°。与未经修饰的心包相比,牛血清白蛋白和纤维蛋白原的吸附量分别降低了93.1%和85%,抗血栓能力大大增强。