Ultra-Low Cost, Facile Fabrication of Transparent Neural Electrode Array for Electrocorticography with Photoelectric Artifact-Free Optogenetics,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Ultra-Low Cost, Facile Fabrication of Transparent Neural Electrode Array for Electrocorticography with Photoelectric Artifact-Free Optogenetics
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2021-11-28 , DOI: 10.1002/adfm.202105568
Young Uk Cho ₁ , Ju Young Lee ₁ , Ui‐Jin Jeong _{2,

3} , Sang Hoon Park ₁ , Se Lin Lim ₁ , Kyung Yeun Kim _{4,

5} , Je Wu Jang ₁ , Jong Ho Park ₆ , Hyun Woo Kim ₁ , Hyogeun Shin ₂ , Ho Jeong Jeon _{4,

7} , Young Mee Jung _{8,

9} , Il‐Joo Cho _{2,

10,

11} , Ki Jun Yu _{1,

11}

Affiliation

Department of Electrical and Electronic Engineering Yonsei University 50 Yonsei‐ro, Seodaemun‐gu Seoul 03722 Korea
Center for Bio‐Microsystems Brain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea
School of Electrical Engineering Korea University Seoul 02841 Republic of Korea
Center for Biomaterials Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea
Department of Mechanical Engineering Seoul National University Seoul 08826 Republic of Korea
School of Business Yonsei University 50 Yonsei‐ro, Seodaemun‐gu Seoul 03722 Korea
KU‐KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea
Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea
School of Electrical and Electronic Engineering YU‐KIST Institute Yonsei University Seoul 03722 Republic of Korea
School of Electrical and Electronics Engineering Yonsei University Seoul 03722 Republic of Korea
Yonsei‐KIST Convergence Research Institute Yonsei University Seoul 03722 Republic of Korea

Transparent implantable devices have received significant attention in neuroscience and biomedical engineering by combining neural recording and optical modalities. Opaque, metal-based electrode arrays for electrophysiology block optical imaging and cause photoelectric artifacts, making them difficult to integrate with optogenetics. Here, a photoelectric artifact-free, highly conductive, and transparent poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) electrode array is introduced as promising neural implants. The technology which is developed in this work provides transparent neural interfaces through low-cost, ultra-facile method compared with other transparent materials being applied to implantable tools. The device exhibits superior optical, mechanical, and electrical characteristics to other studies, thanks to a simple ethylene glycol immersing process. The device performance is highlighted by comparing its light stimulation efficiency and photoelectric artifact extent with conventional thin gold electrodes both in vitro and in vivo. This platform can assemble transparent neural interfaces much more efficiently than any other material candidates and thus has many potential applications.

中文翻译：

具有光电无伪影光遗传学的用于皮层电描记术的透明神经电极阵列的超低成本、简便制造

通过结合神经记录和光学方式，透明可植入设备在神经科学和生物医学工程中受到了广泛关注。用于电生理学的不透明金属电极阵列会阻碍光学成像并导致光电伪影，使其难以与光遗传学集成。在这里，介绍了一种无光电伪影、高导电性和透明的聚 (3,4-乙烯二氧噻吩) 聚苯乙烯磺酸 (PEDOT:PSS) 电极阵列作为有前途的神经植入物。与应用于可植入工具的其他透明材料相比，这项工作中开发的技术通过低成本、超简便的方法提供了透明的神经接口。该设备表现出优于其他研究的光学、机械和电气特性，得益于简单的乙二醇浸渍工艺。通过在体外和体内将其光刺激效率和光电伪影程度与传统的薄金电极进行比较，突出了器件的性能。该平台可以比任何其他候选材料更有效地组装透明神经接口，因此具有许多潜在的应用。

更新日期：2021-11-28

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南