Influence of water-soluble pillararene hosts on Kemp elimination,RSC Advances

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Influence of water-soluble pillararene hosts on Kemp elimination
RSC Advances ( IF 3.9 ) Pub Date : 2021-11-26 , DOI: 10.1039/d1ra07958a
Qian Liu ₁ , Xueqi Tian ₁ , Yuhong Shen ₁ , Xingyi Huang ₁ , Kaiya Wang ₁ , Xiao-Yu Hu ₁

Affiliation

Since pillar[5]arene was first discovered in 2008, it has developed into a multifunctional supramolecular host. Its application covers many fields from drug delivery and chemical sensing to the construction of molecular machines, and so on. Supramolecular catalysis based on pillar[n]arenes is one of the hot research topics that has emerged in recent years. In this paper, we have synthesized two water-soluble pillar[5]arenes with peripheral rims bearing opposite charges and investigated their influence on Kemp elimination reaction of 1,2-phenylisoxazole derivatives. It is found that both hosts have a moderate rate acceleration effect on the reaction, and the positively charged host H1 has a greater impact on the reaction rate than the negatively charged host H2.

中文翻译：

水溶性柱芳烃主体对 Kemp 消除的影响

自2008年首次发现柱[5]芳烃以来，它已发展成为一种多功能的超分子主体。它的应用涵盖了从药物输送和化学传感到分子机器的构建等多个领域。基于柱[ n ]芳烃的超分子催化是近年来兴起的研究热点之一。在本文中，我们合成了两种水溶性柱[5]芳烃，其外围边缘带有相反的电荷，并研究了它们对1,2-苯基异恶唑衍生物的Kemp消除反应的影响。发现两种主体对反应都有中等的速率加速作用，带正电的主体H1比带负电的主体H2对反应速率的影响更大.

更新日期：2021-11-26

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