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The Therapeutic Potential of Saw Palmetto Extract in Urological Disorders
Natural Product Communications ( IF 1.5 ) Pub Date : 2021-11-26 , DOI: 10.1177/1934578x211059635
Meng Liu 1 , Huirong Yin 2 , Fang Wang 1 , Ying Tian 3
Affiliation  

Saw palmetto extract (SPE) has been widely used as a therapeutic remedy for urinary dysfunction in western countries. Furthermore, as an herb drug, it can be used as an alternative therapy for benign prostatic hyperplasia (BPH) due to its safety and minimum adverse effects. Reportedly, SPE improves the urinary symptoms, which mainly depend on anti-androgenic effects and effects on autonomic receptors in the lower urinary tract. However, the mechanisms of action responsible for the therapeutic roles of SPE have not been fully elucidated. Relevant studies indicate that SPE has some positive effects on the treatment of urological diseases in animals, and clinical trials are ongoing. In this review, we summarize the pharmacological properties and discuss the possible therapeutic mechanisms of SPE in urological diseases, including anti-androgenic effects, effects on autonomic receptors in the lower urinary tract, anti-inflammatory activity, anti-proliferative and pro-apoptotic effects, and highlight a potential therapeutic approach in the clinical treatment of patients with BPH, prostate cancer, chronic prostatitis (CP) and erectile dysfunction (ED).



中文翻译:

锯棕榈提取物在泌尿系统疾病中的治疗潜力

锯棕榈提取物 (SPE) 在西方国家已被广泛用作治疗泌尿功能障碍的药物。此外,作为一种草药,由于其安全性和最小的副作用,它可以用作良性前列腺增生 (BPH) 的替代疗法。据报道,SPE改善泌尿系统症状主要依赖于抗雄激素作用和对下尿路自主神经受体的作用。然而,负责 SPE 治疗作用的作用机制尚未完全阐明。相关研究表明,SPE对动物泌尿系统疾病的治疗有一定的积极作用,临床试验正在进行中。在这篇综述中,我们总结了 SPE 的药理特性并讨论了 SPE 在泌尿系统疾病中的可能治疗机制,

更新日期:2021-11-26
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