Photoredox Activation of Organozinc Reagents: Barbier-Type Reaction of Alkyl Halides with α-(Trifluoromethyl)styrenes,Organic Letters

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Photoredox Activation of Organozinc Reagents: Barbier-Type Reaction of Alkyl Halides with α-(Trifluoromethyl)styrenes
Organic Letters ( IF 4.9 ) Pub Date : 2021-11-24 , DOI: 10.1021/acs.orglett.1c03917
Anton A Gladkov _{1,

2} , Grigory N Chernov _{1,

2} , Vitalij V Levin ₁ , Vladimir A Kokorekin ₁ , Alexander D Dilman ₁

Affiliation

Organozinc reagents may be activated under blue light irradiation using an organic photocatalyst to generate alkyl radicals. The radicals are trapped by α-(trifluoromethyl)styrenes leading to gem-difluorinated products after elimination of fluoride. The reaction can be conveniently performed under Barbier conditions starting from organic iodides and bromides and elemental zinc.

中文翻译：

有机锌试剂的光氧化还原活化：烷基卤与 α-（三氟甲基）苯乙烯的 Barbier 型反应

有机锌试剂可以在蓝光照射下使用有机光催化剂活化以产生烷基自由基。自由基被 α-（三氟甲基）苯乙烯捕获，在消除氟化物后产生宝石二氟化产物。从有机碘化物和溴化物以及元素锌开始，该反应可以在巴比耶条件下方便地进行。

更新日期：2021-12-17

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