We have modified the surface of poly(lactic acid) (PLA) by bromination in the presence of N-bromosuccinimide (NBS) under UV irradiation. This new approach to impart functionality to the surface does not effect the bulk of the material. Brominated PLA surfaces served as initiators for atom-transfer radical polymerization (SI-ATRP) of 2-(methacryloyloxy)ethyl]trimethylammonium chloride, a quaternary ammonium methacrylate (QMA). Grafting of poly(QMA) brushes rendered PLA films hydrophilic and these films displayed a three-order of magnitude increase in antimicrobial efficacy against Gram-negative bacteria such as Escherichia coli as compared to unmodified PLA. The two-step strategy described here to modify PLA surface represents a useful route to modified PLA materials for biomedical and antimicrobial packaging applications.

我们已经在紫外线照射下在N-溴代琥珀酰亚胺 (NBS)存在下通过溴化来改性聚乳酸​​ (PLA) 的表面。这种赋予表面功能的新方法不会影响材料的主体。溴化 PLA 表面用作 2-(甲基丙烯酰氧基)乙基] 三甲基氯化铵（一种甲基丙烯酸季铵 (QMA)）的原子转移自由基聚合 (SI-ATRP) 的引发剂。聚 (QMA) 刷子的接枝使 PLA 薄膜具有亲水性，这些薄膜对革兰氏阴性细菌（如大肠杆菌）的抗菌功效提高了三个数量级与未修改的PLA相比。此处描述的改性 PLA 表面的两步策略代表了一条用于生物医学和抗菌包装应用的改性 PLA 材料的有用途径。