This review deals with the synthetic methods, chemical reactions, and applications of triazolopyrimidine derivatives. The synthetic methods and chemical reactions are subdivided into groups according to the junction between triazole and pyrimidine moieties for instance [1,2,4]triazolo[1,5- a]pyrimidine, [1,2,4]triazolo[1,5-c]pyrimidine, [1,2,3]triazolo[1,5-a]pyrimidine, [1,2,3]triazolo[1,5- c]pyrimidine, [1,2,4]triazolo[4,3-c]pyrimidine, and [1,2,4]triazolo[4,3-a]pyrimidine. Pharmacological activity of triazolopyrimidins is also reported.

中文翻译：

---

三唑并嘧啶化学的新动向及其应用

本综述涉及三唑并嘧啶衍生物的合成方法、化学反应和应用。合成方法和化学反应根据三唑和嘧啶部分之间的连接进行细分，例如[1,2,4]三唑并[1,5-a]嘧啶、[1,2,4]三唑并[1,5] -c]嘧啶，[1,2,3]三唑并[1,5-a]嘧啶，[1,2,3]三唑并[1,5-c]嘧啶，[1,2,4]三唑并[4， 3-c]嘧啶和[1,2,4]三唑并[4,3-a]嘧啶。还报道了三唑并嘧啶的药理活性。