薯蓣皂苷元是一种甾体化合物：一种新兴的癌症治疗方法,Journal of Food Biochemistry

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薯蓣皂苷元是一种甾体化合物：一种新兴的癌症治疗方法
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2021-11-19 , DOI: 10.1111/jfbc.14005
Prajya Arya ₁ , Pradyuman Kumar ₁

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通过常见的食物成分忍受各自的癌症研究已经变得更加突出，最好是微不足道的毒性。香料正在成为具有治愈癌症潜力的生物活性化合物的新来源。胡芦巴富含薯蓣皂苷元，对各种癌症具有治疗和预防作用。癌症通过改变细胞受体侵入各种细胞机制。癌症通过改变细胞受体（如 p38、p53、mTOR、Akt 和 PARP）来伪造健康细胞。癌症发展的不同阶段是由各种细胞机制触发的。薯蓣皂苷元有助于抑制癌症机制并诱导程序性细胞死亡。薯蓣皂苷元带来了肺癌、乳腺癌、前列腺癌、肝癌和结肠癌治疗线的变化。细胞凋亡改变细胞质不同的半胱天冬酶途径并触发癌细胞系死亡的选定序列。细胞死亡由金属蛋白酶 caspase 进行的一系列事件组成。本文就薯蓣皂苷元对癌症、半胱天冬酶、细胞死亡和细胞受体之间的复杂关系进行了综述。薯蓣皂苷元在制造癌症、其触发位点以及导致异常细胞凋亡的各种方法中的应用。本文重点研究薯蓣皂苷元，其在预防不同癌症和细胞凋亡中的作用贯穿不同途径，涉及生物活性化合物-细胞机制癌症的复杂相互作用。本文就薯蓣皂苷元对细胞受体进行了综述。薯蓣皂苷元在制造癌症、其触发位点以及导致异常细胞凋亡的各种方法中的应用。本文重点研究薯蓣皂苷元，其在预防不同癌症和细胞凋亡中的作用贯穿不同途径，涉及生物活性化合物-细胞机制癌症的复杂相互作用。本文就薯蓣皂苷元对细胞受体进行了综述。薯蓣皂苷元在制造癌症、其触发位点以及导致异常细胞凋亡的各种方法中的应用。本文重点研究薯蓣皂苷元，其在预防不同癌症和细胞凋亡中的作用贯穿不同途径，涉及生物活性化合物-细胞机制癌症的复杂相互作用。

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Diosgenin a steroidal compound: An emerging way to cancer management

To endure respective research for cancer via common food ingredients has become more prominent with preferably minuscule toxicity. Spices are emerging as a new source of bioactive compounds which have the potential to cure cancer. Fenugreek is rich in diosgenin that has curative and preventive potency toward various cancers. Cancer is invading various cellular mechanisms by altering cellular receptors. Cancer falsifies healthy cells by altered cell receptors like p38, p53, mTOR, Akt, and PARP. Distinct stages of cancer development are triggered by various cellular mechanisms. Diosgenin helps in suppressing cancer mechanisms and induces programmed cell death. Diosgenin brought changes in treatment line of lung, breast, prostate, liver, and colon cancer. Apoptosis changes cytoplasmic different caspase pathways and triggers selected sequence for cancer cell line death. Cell death comprised of series of events carried out by metalloprotease caspase. The complex relationship among cancer, caspase, cell death, and cellular receptors is reviewed in this article in respect of diosgenin. The utilization of diosgenin in creating a bar for cancer, its triggering sites, and various ways to cause apoptosis of abnormal cells. This article focused on diosgenin, its role in the prevention of different cancer and cellular apoptosis throughout different pathways involved in complex interaction of bioactive compound-cellular mechanism cancer.

更新日期：2021-12-09

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