Biosensors and Bioelectronics ( IF 10.7 ) Pub Date : 2021-11-18 , DOI: 10.1016/j.bios.2021.113816
Florian Vogelbacher 1 , Tim Kothe 1 , Paul Muellner 1 , Eva Melnik 1 , Martin Sagmeister 2 , Jochen Kraft 2 , Rainer Hainberger 1
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Single-mode organic solid-state lasers with direct emission into an optical waveguide are attractive candidates for cost-efficient coherent light sources employed in photonic lab-on-a-chip biosensors. Here, we present a combination of a dye-doped organic solid-state distributed feedback laser with a highly sensitive optical waveguide Mach-Zehnder interferometer on a silicon nitride photonic platform. This organic-hybrid laser allows for optical pumping with a laser diode in an alignment tolerant manner, which facilitates applications in point-of-care diagnostics. The sensitivity to bulk refractive index changes and the concentration dependent binding of streptavidin on a polyethyleneimine-biotin functionalized surface was studied to demonstrate the practicability of this cost-efficient coherent light source for optical waveguide biosensors.
中文翻译:
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具有激光二极管泵浦集成单模氮化硅有机混合固态激光器的波导 Mach-Zehnder 生物传感器
直接发射到光波导中的单模有机固态激光器是光子实验室生物传感器中采用的具有成本效益的相干光源的有吸引力的候选者。在这里,我们在氮化硅光子平台上展示了染料掺杂有机固态分布式反馈激光器与高灵敏度光波导 Mach-Zehnder 干涉仪的组合。这种有机混合激光器允许以允许对准的方式使用激光二极管进行光泵浦,从而促进了床旁诊断的应用。研究了对体积折射率变化的敏感性和链霉亲和素在聚乙烯亚胺-生物素功能化表面上的浓度依赖性结合,以证明这种具有成本效益的相干光源用于光波导生物传感器的实用性。