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Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-11-17 , DOI: 10.1002/adhm.202101984
He Ding 1 , Jinhu Chang 1 , Fei He 1 , Shili Gai 1 , Piaoping Yang 1
Affiliation  

Advances in nanotechnology have enabled the rapid development of stimuli-responsive therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H2S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H2S-responsive properties, as new-generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H2S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H2S. This review summarizes the state-of-art research on H2S-related nanomedicines. In particular, recent advances in H2S therapeutics for cancer, such as H2S-mediated gas therapy and H2S-related synergistic therapies (combined with chemotherapy, photodynamic therapy, photothermal therapy, and chemodynamic therapy) are highlighted. Versatile imaging techniques for real-time monitoring H2S during biological diagnosis are reviewed. Finally, the biosafety issues, current challenges, and potential possibilities in the evolution of H2S-based therapy that facilitate clinical translation to patients are discussed.

中文翻译:

硫化氢:一种新兴的气体治疗精准策略

纳米技术的进步使用于精确气体治疗的刺激响应治疗纳米材料的快速发展成为可能。硫化氢(H 2 S)是一种重要的气体信号分子,具有内在的生化特性,在正常和病理条件下均发挥其多种生理作用。探索各种具有 H 2 S 响应特性的纳米材料作为新一代治疗剂,以指导生物环境中的治疗行为。H 2 S的交叉学科是研究H 2 S的化学性质、生物学机制和治疗作用的新兴科学热点。本综述总结了H 2最新研究进展。S相关的纳米药物。特别强调了H 2 S 治疗癌症的最新进展,例如H 2 S 介导的气体疗法和H 2 S 相关的协同疗法(与化学疗法、光动力疗法、光热疗法和化学动力疗法相结合)。回顾了在生物诊断过程中用于实时监测 H 2 S 的多功能成像技术。最后,讨论了促进临床转化为患者的 H 2 S 疗法发展过程中的生物安全问题、当前挑战和潜在可能性。
更新日期:2021-11-17
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