Polarization-Resolved Electrochemiluminescence Sensor Based on the Surface Plasmon Coupling Effect of a Au Nanotriangle-Patterned Structure,Analytical Chemistry

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Polarization-Resolved Electrochemiluminescence Sensor Based on the Surface Plasmon Coupling Effect of a Au Nanotriangle-Patterned Structure
Analytical Chemistry ( IF 6.7 ) Pub Date : 2021-11-17 , DOI: 10.1021/acs.analchem.1c04120
Peilin Wang ₁ , Junyi Zhao _{2,

3} , Zizhun Wang ₄ , Zihui Liang ₁ , Yixin Nie ₁ , Shuping Xu _{2,

3} , Qiang Ma ₁

Affiliation

This work focused on the construction of a nanomaterial-patterned structure for high-resolved ECL signal modulation. Due to the surface coupling effect, the different shapes and distribution states of surface plasmonic nanomaterials not only affect the luminescence intensity enhancement but also decide the electrochemiluminescence (ECL) polarization characteristics. Herein, tin disulfide quantum dots were synthesized via a solvothermal method as ECL emitters. Compared with other nanostructures, Au nanotriangle (Au NT) displayed both the localized surface plasmon resonance electromagnetic enhancement effect and the tip amplification effect, which had significant hot spot regions at three sharp tips. Therefore, self-assembled Au NT-based patterned structures with high density and uniform hot spots were constructed as ideal surface plasmonic materials. More importantly, the distribution states of the hot spots affect the polarization characteristics of ECL, resulting in directional ECL emission at different angles. As a result, a polarization-resolved ECL biosensor was designed to detect miRNA 221. Moreover, this polarization-resolved biosensor achieved good quantitative detection in the linear range of 1 fM to 1 nM and showed satisfactory results in the analysis of the triple-negative breast cancer patients’ serum.

中文翻译：

基于 Au 纳米三角形图案结构的表面等离子体耦合效应的偏振分辨电化学发光传感器

这项工作的重点是构建用于高分辨率 ECL 信号调制的纳米材料图案结构。由于表面耦合效应，表面等离子体纳米材料的不同形状和分布状态不仅影响发光强度增强，而且决定电化学发光（ECL）偏振特性。在此，通过溶剂热法合成了二硫化锡量子点作为 ECL 发射体。与其他纳米结构相比，Au 纳米三角形（Au NT）同时表现出局域表面等离子体共振电磁增强效应和尖端放大效应，在三个尖锐的尖端具有显着的热点区域。所以，具有高密度和均匀热点的自组装 Au NT 基图案结构被构建为理想的表面等离子体材料。更重要的是，热点的分布状态影响ECL的偏振特性，导致不同角度的定向ECL发射。因此，设计了一种偏振分辨 ECL 生物传感器来检测 miRNA 221。此外，这种偏振分辨生物传感器在 1 fM 至 1 nM 的线性范围内实现了良好的定量检测，并在三阴性的分析中显示出令人满意的结果。乳腺癌患者的血清。

更新日期：2021-11-30

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