硫化铜纳米结构：易合成、光催化和多柔比星抗癌药物递送应用,New Journal of Chemistry

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硫化铜纳米结构：易合成、光催化和多柔比星抗癌药物递送应用
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2021-11-01 , DOI: 10.1039/d1nj04618g
Zahra Rafiee ₁ , Fatemeh Davar ₁ , Saeed Hasani ₂ , Ali Majedi _{1,

3} , Ahmed Esmail Shalan _{4,

5}

Affiliation

在这项研究中，利用水回流法合成了不同形态的硫化铜纳米结构，如花状纳米片和球形纳米颗粒。该反应在油酸介质中进行，分别使用乙酰丙酮酸铜( II ) [Cu(acac) ₂ ] 和元素硫作为Cu ²⁺和S ^2-源。然后，研究了回流温度、前体摩尔比和反应时间对合成颗粒相和形貌的影响。结果表明，在 200 °C 回流温度下，[Cu (acac) ₂ ] 与 S ^{2- 的}比例为 1:1显示出形成纯六方 Cu _{7.2 的}最佳条件S ₄相。然后，合成的Cu _7.2 S ₄的表面也被亲水性聚乙二醇(PEG)修饰，修饰后的纳米粒子用于体外条件下pH = 5.4、pH = 7.4的药物阿霉素的释放，这是紫外可见分光光度计监测。结果表明，酸性条件下的药物释放量大于中性条件下的释放量。此外，通过增加硫含量，样品的形态从球形变为花状纳米片，并且相趋向于 CuS 相。最后合成的Cu _7.2 S ₄纳米结构用于光催化降解一些染料，包括活性蓝 21 (RB21)、活性红 120 (RR120) 和活性橙 5 (RO5)。结果表明，RB21 颜料的最高降解率为 99%。

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Copper sulfide nanostructures: easy synthesis, photocatalytic and doxorubicin anticancer drug delivery applications

In this research, an aqueous reflux method was utilized to synthesize copper sulfide nanostructures with different morphologies, such as flower-like based nanosheets and spherical nanoparticles. The reaction was performed in oleic acid medium, using copper(II) acetylacetonate [Cu(acac)₂] and elemental sulfur as the Cu²⁺ and S²⁻ sources, respectively. Then, the effect of refluxing temperature, precursor molar ratios and reaction time on the particle phase and morphology of synthesized particles was investigated. The results show that a 1 : 1 ratio of [Cu (acac)₂] to S²⁻ at 200 °C reflux temperature for 10 h exhibit optimum conditions for forming a pure hexagonal Cu_7.2S₄ phase. Then, the surface of the synthesized Cu_7.2S₄ was also modified by hydrophilic polyethylene glycol (PEG), and the modified nanoparticles were used in the release of the drug doxorubicin at pH = 5.4, pH = 7.4 under in vitro conditions, which was monitored by UV-Vis spectroscopy. The results showed that drug release under acidic conditions is greater than that under neutral conditions. Furthermore, by increasing the sulfur content, the sample's morphology was changed from a spherical shape to flower-liked based nanosheets, and the phase tends to be the CuS phase. Finally, the synthesized Cu_7.2S₄ nanostructures were used for the photocatalytic degradation of some dyes, including Reactive Blue 21 (RB21), Reactive Red 120 (RR120), and Reactive Orange 5 (RO5). The results showed that the highest degradation percentage for RB21 pigment was 99%.

更新日期：2021-11-18

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