Dearomatization–rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Dearomatization–rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions
Chemical Communications ( IF 4.3 ) Pub Date : 2021-11-10 , DOI: 10.1039/d1cc04191f
Pengxin Wang _{1,

2} , Yulian Cheng ₂ , Chunlei Wu ₂ , Ruixiang Luo ₂ , Caibing Ma ₂ , Yimin Zhou ₂ , Zhilong Ma ₂ , Rui Wang ₁ , Wu Su ₂ , Lijing Fang ₂

Affiliation

We have developed a dearomatization–rearomatization strategy for the modification of peptides/proteins through a thiol-Michael addition to the electrophilic cyclohexadienone intermediate that is generated in situ via the oxidation of tyrosine. This strategy enriches the conjugation toolbox and has great potential for applications in medicinal chemistry and chemical biology.

中文翻译：