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Comprehensive Review on Design and Manufacturing of Bio-scaffolds for Bone Reconstruction
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-11-17 , DOI: 10.1021/acsabm.1c00949
Jishita Ravoor 1 , Mahendran Thangavel 1 , Renold Elsen S 1
Affiliation  

Bio-scaffolds are synthetic entities widely employed in bone and soft-tissue regeneration applications. These bio-scaffolds are applied to the defect site to provide support and favor cell attachment and growth, thereby enhancing the regeneration of the defective site. The progressive research in bio-scaffold fabrication has led to identification of biocompatible and mechanically stable materials. The difficulties in obtaining grafts and expenditure incurred in the transplantation procedures have also been overcome by the implantation of bio-scaffolds. Drugs, cells, growth factors, and biomolecules can be embedded with bio-scaffolds to provide localized treatments. The right choice of materials and fabrication approaches can help in developing bio-scaffolds with required properties. This review mostly focuses on the available materials and bio-scaffold techniques for bone and soft-tissue regeneration application. The first part of this review gives insight into the various classes of biomaterials involved in bio-scaffold fabrication followed by design and simulation techniques. The latter discusses the various additive, subtractive, hybrid, and other improved techniques involved in the development of bio-scaffolds for bone regeneration applications. Techniques involving multimaterial printing and multidimensional printing have also been briefly discussed.

中文翻译:

骨重建生物支架的设计与制造综述

生物支架是广泛用于骨骼和软组织再生应用的合成实体。这些生物支架被应用于缺陷部位以提供支持并有利于细胞附着和生长,从而增强缺陷部位的再生。生物支架制造的进步研究导致了生物相容性和机械稳定材料的鉴定。植入生物支架也克服了获得移植物的困难和移植过程中产生的费用。药物、细胞、生长因子和生物分子可以嵌入生物支架以提供局部治疗。正确选择材料和制造方法有助于开发具有所需特性的生物支架。本综述主要关注用于骨和软组织再生应用的可用材料和生物支架技术。本综述的第一部分深入了解了生物支架制造中涉及的各类生物材料,然后是设计和模拟技术。后者讨论了用于骨再生应用的生物支架开发中涉及的各种加法、减法、混合和其他改进技术。还简要讨论了涉及多材料打印和多维打印的技术。后者讨论了用于骨再生应用的生物支架开发中涉及的各种加法、减法、混合和其他改进技术。还简要讨论了涉及多材料打印和多维打印的技术。后者讨论了用于骨再生应用的生物支架开发中涉及的各种加法、减法、混合和其他改进技术。还简要讨论了涉及多材料打印和多维打印的技术。
更新日期:2021-12-20
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