多神经递质对 DNA 介导的基于 Förster 的共振能量转移的影响：导致白光产生的途径,The Journal of Physical Chemistry B

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多神经递质对 DNA 介导的基于 Förster 的共振能量转移的影响：导致白光产生的途径
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2021-11-16 , DOI: 10.1021/acs.jpcb.1c06836
Arghajit Pyne ₁ , Sourav Nandi ₁ , Souvik Layek ₁ , Meghna Ghosh ₁ , Pratyush Kiran Nandi ₁ , Nanigopal Bera ₁ , Nilmoni Sarkar ₁

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生理上重要的生物分子多巴胺 (DA) 表现出强烈的自氧化和聚集行为，这些行为已被控制和调节以产生荧光聚多巴胺 (F-PDA) 纳米颗粒。另一方面，为了遵循 Förster共振能量转移（FRET）途径。对这种 DNA 介导的 FRET 在三种介质（pH 7.4 的磷酸盐缓冲盐水 (PBS)、DA 和 F-PDA）中的比较了解得出结论，三种介质中的 FRET 效率遵循以下顺序：PBS > DA > F-掌上电脑。荧光 F-PDA 矩阵中的这种受控 FRET 为高效白光 (WL) 生成发挥了关键作用，具有与纯 WL 发射良好匹配的优秀国际照明委员会 (CIE) 参数。已证明所获得的 WL 发射对于不同参与组分的浓度和照明源的激发波长非常具体。此外，已观察到 WL 发射溶液的光学特性在众所周知的琼脂糖凝胶基质内保持良好。最后，已经详细建立了这种基于 FRET 的 WL 生成背后的机制途径，据我们所知，

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Influence of a Polyneurotransmitter on DNA-Mediated Förster-Based Resonance Energy Transfer: A Path Leading to White Light Generation

The physiologically important biomolecule, dopamine (DA), shows strong self-oxidation and aggregation behaviors, which have been controlled and modulated to result in fluorescent polydopamine (F-PDA) nanoparticles. On the other hand, the simultaneous binding of two diverse deoxyribonucleic acid (DNA) binding probes, 4′,6-diamidino-2-phenylindole dihydrochloride (DAPI) and ethidium bromide (EtBr), has been elaborately established to follow the Förster-based resonance energy transfer (FRET) pathway. The comparative understanding of this DNA-mediated FRET in three media, phosphate buffer saline (PBS) of pH 7.4, DA, and F-PDA, has concluded that the FRET efficiency in the three media follows the order: PBS > DA > F-PDA. This controlled FRET in the fluorescent F-PDA matrix serves a pivotal role for efficient white light (WL) generation with excellent Commission Internationale de l’Eclairage (CIE) parameters that match well with that of pure WL emission. The obtained WL emission has been shown to be very specific with respect to concentrations of different participating components and the excitation wavelength of the illuminating source. Furthermore, the optical properties of the WL emitting solution have been observed to be retained excellently inside the well-known agarose gel matrix. Finally, the mechanistic pathway behind such a FRET-based WL generation has been established in detail, and to the best of our knowledge, the current study offers the first and only report that discloses the influence of a fluorescent polyneurotransmitter matrix for successful generation of WL emission.

更新日期：2021-11-25

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