固定二氧化碳的酵母代谢工程及其应用,Bioresource Technology

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固定二氧化碳的酵母代谢工程及其应用
Bioresource Technology ( IF 9.7 ) Pub Date : 2021-11-17 , DOI: 10.1016/j.biortech.2021.126349
Soo Rin Kim ₁ , Soo-Jung Kim ₂ , Sun-Ki Kim ₃ , Seung-Oh Seo ₄ , Sujeong Park ₁ , Jamin Shin ₁ , Jeong-Sun Kim ₅ , Bo-Ram Park ₆ , Yong-Su Jin ₇ , Pahn-Shick Chang ₈ , Yong-Cheol Park ₉

Affiliation

School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea.
Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea.
Department of Food Science and Technology, Chung-Ang University, Anseong, Gyeonggi 17546, Republic of Korea.
Department of Food Science and Nutrition, The Catholic University of Korea, Bucheon 14662, Republic of Korea.
Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Department of Agro-food Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea.
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea.

由于许多工业生物过程依赖于酵母发酵，因此开发固定 CO ₂的酵母菌株可能是实现可持续工业过程和碳中和的一个有吸引力的选择。最近的研究表明，1,5-二磷酸核酮糖羧化酶加氧酶 (RuBisCO) 在酵母中的表达，例如酿酒酵母和马克斯克鲁维酵母，能够实现混合营养 CO ₂ 固定和生物燃料的生产。此外，在毕赤酵母中表达的合成 Calvin-Benson-Bassham (CBB) 循环（包括 RuBisCO）能够在 CO ₂上实现自养生长。本综述重点介绍了实现 CO _{2的代谢工程策略的最新进展} 固定在酵母中。此外，我们还讨论了独立于 RuBisCO 的其他天然和合成代谢途径在开发能够产生增值生化物质的CO _{2固定酵母菌株方面的潜力。}

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更新日期：2021-11-17

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