Boosting Chemodynamic Therapy via a Synergy of Hypothermal Ablation and Oxidation Resistance Reduction,ACS Applied Materials & Interfaces

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Boosting Chemodynamic Therapy via a Synergy of Hypothermal Ablation and Oxidation Resistance Reduction
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-11-15 , DOI: 10.1021/acsami.1c16835
Junlie Yao _{1,

2} , Fang Yang _{1,

3} , Fang Zheng ₁ , Chenyang Yao _{1,

2} , Jie Xing _{1,

2} , Xiawei Xu ₁ , Aiguo Wu _{1,

3}

Affiliation

Chemodynamic therapy (CDT), deemed as a cutting-edge antineoplastic therapeutic tactics, efficaciously suppresses tumors via catalytically yielding hydroxyl radicals (^•OH) in tumor regions. Nevertheless, its biomedical applications are often restricted by the limited hydrogen peroxide (H₂O₂) level and upregulated antioxidant defense. Herein, a versatile nanoreactor is elaborately designed via integrating Cu_2–xS and MnO₂ for T₁-weighted magnetic resonance (MR) imaging-guided CDT, synergistically enhanced through hypothermal ablation and oxidation resistance reduction, thereby displaying splendid antitumor efficiency as well as suppression on pulmonary metastasis. The as-synthesized Cu_2–xS@MnO₂ nanoreactors afford acid-dependent Cu-based and glutathione (GSH)-activated Mn-based catalytic properties for bimodal CDT. Owing to excellent absorbance at the second near-infrared (NIR-II) window, the Cu_2–xS furnishes hypo-photo-thermal therapy (PTT) against tumor growth and ameliorates the catalytic performance for thermal-enhanced CDT. Additionally, MnO₂ significantly downregulates GSH and glutathione peroxidase 4, which synergistically boosts CDT via promoting oxidative stress, simultaneously generating Mn²⁺ for MR contrast improvement and activatable tumor imaging. Therefore, this study proffers a new attempt centered on the collaborative strategy integrating NIR-II hypothermal PTT and synergistically enhanced CDT for tumor eradication.

中文翻译：

通过低温消融和降低氧化抗性的协同作用促进化学动力学治疗

化学动力学疗法（CDT）被认为是一种尖端的抗肿瘤治疗策略，通过在肿瘤区域催化产生羟基自由基（^• OH）来有效抑制肿瘤。然而，它的生物医学应用通常受到有限的过氧化氢 (H ₂ O ₂ ) 水平和上调的抗氧化防御的限制。在此，通过将 Cu _{2– x} S 和 MnO ₂集成为T ₁精心设计了一种多功能纳米反应器加权磁共振（MR）成像引导的CDT，通过低温消融和抗氧化性降低协同增强，从而显示出出色的抗肿瘤效率以及对肺转移的抑制。合成后的 Cu _{2– x} S@MnO ₂纳米反应器为双峰 CDT 提供了酸依赖性 Cu 基和谷胱甘肽 (GSH) 激活的 Mn 基催化性能。由于在第二近红外 (NIR-II) 窗口具有出色的吸光度，Cu _{2– x} S 提供了针对肿瘤生长的低光热疗法 (PTT) 并改善了热增强 CDT 的催化性能。此外，MnO ₂显着下调 GSH 和谷胱甘肽过氧化物酶 4，通过促进氧化应激协同促进 CDT，同时产生 Mn ²⁺用于 MR 对比度改善和可激活的肿瘤成像。因此，本研究提供了一种新的尝试，围绕整合 NIR-II 低温 PTT 和协同增强 CDT 根除肿瘤的协作策略。

更新日期：2021-11-24

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