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Boosting Chemodynamic Therapy via a Synergy of Hypothermal Ablation and Oxidation Resistance Reduction
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2021-11-15 , DOI: 10.1021/acsami.1c16835
Junlie Yao 1, 2 , Fang Yang 1, 3 , Fang Zheng 1 , Chenyang Yao 1, 2 , Jie Xing 1, 2 , Xiawei Xu 1 , Aiguo Wu 1, 3
Affiliation  

Chemodynamic therapy (CDT), deemed as a cutting-edge antineoplastic therapeutic tactics, efficaciously suppresses tumors via catalytically yielding hydroxyl radicals (OH) in tumor regions. Nevertheless, its biomedical applications are often restricted by the limited hydrogen peroxide (H2O2) level and upregulated antioxidant defense. Herein, a versatile nanoreactor is elaborately designed via integrating Cu2–xS and MnO2 for T1-weighted magnetic resonance (MR) imaging-guided CDT, synergistically enhanced through hypothermal ablation and oxidation resistance reduction, thereby displaying splendid antitumor efficiency as well as suppression on pulmonary metastasis. The as-synthesized Cu2–xS@MnO2 nanoreactors afford acid-dependent Cu-based and glutathione (GSH)-activated Mn-based catalytic properties for bimodal CDT. Owing to excellent absorbance at the second near-infrared (NIR-II) window, the Cu2–xS furnishes hypo-photo-thermal therapy (PTT) against tumor growth and ameliorates the catalytic performance for thermal-enhanced CDT. Additionally, MnO2 significantly downregulates GSH and glutathione peroxidase 4, which synergistically boosts CDT via promoting oxidative stress, simultaneously generating Mn2+ for MR contrast improvement and activatable tumor imaging. Therefore, this study proffers a new attempt centered on the collaborative strategy integrating NIR-II hypothermal PTT and synergistically enhanced CDT for tumor eradication.

中文翻译:

通过低温消融和降低氧化抗性的协同作用促进化学动力学治疗

化学动力学疗法(CDT)被认为是一种尖端的抗肿瘤治疗策略,通过在肿瘤区域催化产生羟基自由基( OH)来有效抑制肿瘤。然而,它的生物医学应用通常受到有限的过氧化氢 (H 2 O 2 ) 水平和上调的抗氧化防御的限制。在此,通过将 Cu 2– x S 和 MnO 2集成为T 1精心设计了一种多功能纳米反应器加权磁共振(MR)成像引导的CDT,通过低温消融和抗氧化性降低协同增强,从而显示出出色的抗肿瘤效率以及对肺转移的抑制。合成后的 Cu 2– x S@MnO 2纳米反应器为双峰 CDT 提供了酸依赖性 Cu 基和谷胱甘肽 (GSH) 激活的 Mn 基催化性能。由于在第二近红外 (NIR-II) 窗口具有出色的吸光度,Cu 2– x S 提供了针对肿瘤生长的低光热疗法 (PTT) 并改善了热增强 CDT 的催化性能。此外,MnO 2显着下调 GSH 和谷胱甘肽过氧化物酶 4,通过促进氧化应激协同促进 CDT,同时产生 Mn 2+用于 MR 对比度改善和可激活的肿瘤成像。因此,本研究提供了一种新的尝试,围绕整合 NIR-II 低温 PTT 和协同增强 CDT 根除肿瘤的协作策略。
更新日期:2021-11-24
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