Aggregation-Induced Emission Luminogens with Photoresponsive Behaviors for Biomedical Applications,Advanced Healthcare Materials

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Aggregation-Induced Emission Luminogens with Photoresponsive Behaviors for Biomedical Applications
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-11-15 , DOI: 10.1002/adhm.202101169
Jiaqiang Wang ₁ , Liyao Zhang ₂ , Zhen Li _{1,

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Affiliation

Fluorescent biomedical materials can visualize subcellular structures and therapy processes in vivo. The aggregation-induced emission (AIE) phenomenon helps suppress the quenching effect in the aggregated state suffered by conventional fluorescent materials, thereby contributing to design strategies for fluorescent biomedical materials. Photoresponsive biomedical materials have attracted attention because of the inherent advantages of light; i.e., remote control, high spatial and temporal resolution, and environmentally friendly characteristics, and their combination with AIE facilitates development of fluorescent molecules with efficient photochemical reactions upon light irradiation. In this review, organic compounds with AIE features for biomedical applications and design strategies for photoresponsive AIE luminogens (AIEgens) are first summarized briefly. Applications are then reviewed, with the employment of photoresponsive and AIE-active molecules for photoactivation imaging, super-resolution imaging, light-induced drug delivery, photodynamic therapy with photochromic behavior, and bacterial targeting and killing being discussed at length. Finally, the future outlook for AIEgens is considered with the aim of stimulating innovative work for further development of this field.

中文翻译：

用于生物医学应用的具有光响应行为的聚集诱导发光发光材料

荧光生物医学材料可以在体内可视化亚细胞结构和治疗过程。聚集诱导发射（AIE）现象有助于抑制传统荧光材料在聚集状态下的猝灭效应，从而有助于荧光生物医学材料的设计策略。光响应生物医学材料由于光的固有优势而备受关注；即远程控制、高时空分辨率和环境友好特性，以及它们与AIE的结合促进了在光照射下具有高效光化学反应的荧光分子的发展。在本次审查中，首先简要总结了用于生物医学应用的具有 AIE 特征的有机化合物和光响应 AIE 发光体 (AIEgens) 的设计策略。然后回顾了应用，并详细讨论了使用光响应和 AIE 活性分子进行光活化成像、超分辨率成像、光诱导药物递送、光致变色行为的光动力疗法以及细菌靶向和杀灭。最后，考虑了 AIEgens 的未来前景，旨在激发创新工作以进一步发展该领域。并详细讨论了细菌靶向和杀灭。最后，考虑了 AIEgens 的未来前景，旨在激发创新工作以进一步发展该领域。并详细讨论了细菌靶向和杀灭。最后，考虑了 AIEgens 的未来前景，旨在激发创新工作以进一步发展该领域。

更新日期：2021-12-22

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