A direct cross-coupling between 9H-fluoren-9-ols and organic azides for the synthesis of steric hindered 2-amino-2′-ketonyl biaryls was reported. The reaction featured an acid-mediated azidation/ring-expansion/hydrolysis cascade, which formally realized the C–N bond coupling reaction via cleavage of a C–C single bond. This method was applicable to chiral helical structure to give bulky axially chiral biaryls with full stereospecificity.

中文翻译：

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通过酸介导的 9H-Fluoren-9-ols 与有机叠氮化物的开环构建 2-Amino-2'-ketonyl Biaryls

报道了 9 H -fluoren-9-ols 和有机叠氮化物之间的直接交叉偶联，用于合成空间位阻 2-amino-2'-ketonyl biaryls。该反应具有酸介导的叠氮化/扩环/水解级联反应，通过C-C单键的断裂正式实现了C-N键偶联反应。该方法适用于手性螺旋结构，得到具有完全立体定向的大体积轴向手性联芳基化合物。