Increasing access to additive manufacturing technologies utilising easily available desktop devices opened novel ways for formulation of personalized medicines. It is, however, challenging to propose a flexible and robust formulation platform which can be used for fabrication of tailored solid dosage forms composed of APIs with different properties (e.g., hydrophobicity) without extensive optimization. This manuscript presents a strategy for formulation of fast dissolving tablets using binder jetting (BJ) technology. The approach is demonstrated using two model APIs: hydrophilic quinapril hydrochloride (QHCl, logP = 1.4) and hydrophobic clotrimazole (CLO, logP = 5.4). The proposed printing method uses inexpensive, well known, and easily available FDA approved pharmaceutical excipients. The obtained model tablets had uniform content of the drug, excellent mechanical properties, and highly porous structure resulting in short disintegration time and fast dissolution rate. The tablets could be scaled and obtained in predesigned shapes and sizes. The proposed method may find its application in the early stages of drug development where high flexibility of the formulation is required and the amount of available API is limited.

利用易于获得的桌面设备增加对增材制造技术的访问为个性化药物的配制开辟了新途径。然而，提出一个灵活且强大的配方平台是一项挑战，该平台可用于制造由具有不同特性（例如疏水性）的 API 组成的定制固体剂型，而无需进行广泛优化。本手稿介绍了一种使用粘合剂喷射 (BJ) 技术配制快速溶解片剂的策略。该方法使用两种模型 API 进行了演示：亲水性盐酸喹那普利 (QHCl, logP = 1.4) 和疏水性克霉唑 (CLO, logP = 5.4)。所提出的印刷方法使用廉价、众所周知且易于获得的 FDA 批准的药用辅料。得到的模型片药物含量均匀，优异的机械性能和高度多孔的结构，导致崩解时间短，溶解速度快。片剂可以按预先设计的形状和大小进行缩放和获得。所提出的方法可能会在药物开发的早期阶段得到应用，在该阶段需要高度灵活的配方并且可用的 API 数量有限。