<br>全球癌症发病年龄的线性：25 年基于人群的癌症登记研究。,Cancers

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全球癌症发病年龄的线性：25 年基于人群的癌症登记研究。
Cancers ( IF 4.5 ) Pub Date : 2021-11-08 , DOI: 10.3390/cancers13215589
Ettore Bidoli ₁ , Elda Lamaj ₂ , Tiziana Angelin ₁ , Ornella Forgiarini ₂ , Emilia De Santis ₂ , Diego Serraino _{1,

2}

Affiliation

背景仅在乳腺癌中描述了癌症发病中位年龄与基础人群中位年龄之间的线性相关性。我们使用来自全球所有基于人群的癌症登记处 (CR) 的数据，量化了 20 种癌症类型的这种关联的形状和强度。方法从《五大洲癌症发病率》第六卷（1983-1987年）和第十一卷（2008-2012年）列出的所有CR中提取患者的癌症发病中位年龄和潜在人群。通过线性回归模型在横截面水平上评估该关联，并纵向仅考虑整个研究期间（即 25 年跨度）中长期活跃的 CR。结果 2008 年至 2012 年间，人口老龄化中位数每增加一年，男性的所有癌症发病中位年龄就增加近半年，但皮肤癌除外；女性人数增加了 2/3 年。线性模型解释的方差约为 60%。在长期 CR 中，在整个 25 年跨度中观察到前列腺癌和宫颈癌的中位发病年龄有所下降。结论人口老龄化反映了癌症发病中位年龄的 60%。通过检查人口金字塔可以避免对特定年龄组癌症发病率峰值的误解。

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Linearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study.

Background The linear association between median age at cancer onset and median age of the underlying population has been described only for breast cancer. We quantified the shape and strength of such association for 20 cancer types using data from all population-based cancer registries (CRs) worldwide. Methods The patients' median age at cancer onset and of the underlying population were extracted from all CRs listed in volumes VI (1983-1987 years) and XI (2008-2012 years) of Cancer Incidence in Five Continents. The association was assessed at cross-sectional level by linear regression models and longitudinally considering only the long-standing CRs active throughout the study period (i.e., 25-year span). Results During 2008-2012, each one-year increase in median population ageing was associated in men with a nearly half year increase of median age at onset of all cancers, but skin; and a 2/3 year increase in women. Variance explained by linear model was around 60%. In long-standing CRs a decrease in median age at cancer onset was observed for prostate and cervical cancers throughout the 25-year span. Conclusions Population ageing reflected 60% of the median age at cancer onset. Misinterpretation of peaks of cancer incidence in specific age groups may be avoided by examining population pyramids.

更新日期：2021-11-08

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