Multifunctional wound dressings urgently need to be developed to meet the various needs of wound healing. In this work, we first proposed a new method about modifying the guar gum (GG) by performing a quaternization graft reaction and then oxidation. The obtained oxidized quaternized guar gum (OQGG) not only has antibacterial function due to the introduction of quaternary ammonium groups, but also can become one of the components of Schiff base hydrogels due to the presence of aldehyde groups. Therefore, we used it and carboxymethyl chitosan (CMCS) to design a hydrogel with antibacterial, hemostatic, self-repairing and injectable properties. We characterized the structure of OQGG and OQGG@CMCS hydrogels, but also evaluated the performance of the hydrogels. The results showed that GG was successfully modified to OQGG and OQGG@CMCS hydrogel was successfully prepared, and the obtained OQGG@CMCS hydrogel showed excellent antibacterial and hemostatic properties, and exhibited self-healing and injectability. In addition, cytotoxicity tests demonstrated that the OQGG@CMCS hydrogels presented good cytocompatibility. Further, the OQGG@CMCS hydrogel significantly promoted wound healing in an S. aureus-infected rat wound model. Therefore, the hydrogel has the potential to be applied as a wound dressing.

迫切需要开发多功能伤口敷料以满足伤口愈合的各种需求。在这项工作中，我们首先提出了一种通过进行季铵化接枝反应然后氧化来改性瓜尔胶（GG）的新方法。得到的氧化季铵化瓜尔胶(OQGG)不仅由于季铵基团的引入而具有抗菌功能，而且由于醛基团的存在可以成为席夫碱水凝胶的组分之一。因此，我们用它和羧甲基壳聚糖（CMCS）设计了一种具有抗菌、止血、自我修复和可注射特性的水凝胶。我们对 OQGG 和 OQGG@CMCS 水凝胶的结构进行了表征，同时还评估了水凝胶的性能。结果表明，GG成功修饰为OQGG并成功制备OQGG@CMCS水凝胶，所得OQGG@CMCS水凝胶显示出优异的抗菌止血性能，并具有自愈性和可注射性。此外，细胞毒性测试表明 OQGG@CMCS 水凝胶具有良好的细胞相容性。此外，OQGG@CMCS 水凝胶显着促进了金黄色葡萄球菌感染大鼠伤口模型的伤口愈合。因此，水凝胶有可能用作伤口敷料。OQGG@CMCS 水凝胶显着促进金黄色葡萄球菌感染大鼠伤口模型的伤口愈合。因此，水凝胶有可能用作伤口敷料。OQGG@CMCS 水凝胶显着促进金黄色葡萄球菌感染大鼠伤口模型的伤口愈合。因此，水凝胶有可能用作伤口敷料。