Direct C(sp3)–H Sulfonylation of Xanthene Derivatives with Sodium Sulfinates by Oxidative Copper Catalysis,Chinese Journal of Chemistry

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Direct C(sp3)–H Sulfonylation of Xanthene Derivatives with Sodium Sulfinates by Oxidative Copper Catalysis
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2021-11-12 , DOI: 10.1002/cjoc.202100767
Qinghao Song ₁ , He Zhao ₁ , Yanping Sun ₁ , Huanfeng Jiang ₁ , Min Zhang ₁

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By employing a readily available CuCl/DDQ catalyst system, we herein report a direct C(sp³)–H sulfonylation of xanthene derivates with odorless sodium sulfinates. Various 9H-xanthenes, thioxanthenes, and 9,10-dihydroacridines are efficiently transformed into the desired benzylic sulfonyl products via a radical/radical cross-coupling process, proceeding with the merits of broad substrate scope, operational simplicity, good functional group compatibility, and mild reaction conditions.

中文翻译：

氧化铜催化下用亚硫酸钠直接 C(sp3)-H 磺酰化呫吨衍生物

通过使用易于获得的 CuCl/DDQ 催化剂体系，我们在此报告了使用无味亚磺酸钠对呫吨衍生物进行直接 C(sp ³ )-H 磺酰化。各种 9 H-呫吨、噻吨和 9,10-二氢吖啶通过自由基/自由基交叉偶联过程有效转化为所需的苄基磺酰基产物，具有底物范围广、操作简单、官能团兼容性好等优点，和温和的反应条件。

更新日期：2021-12-24

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