Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Multifunctional Magnesium Organic Framework-Based Microneedle Patch for Accelerating Diabetic Wound Healing
ACS Nano ( IF 15.8 ) Pub Date : 2021-11-11 , DOI: 10.1021/acsnano.1c06036 Mengting Yin 1 , Jiayingzi Wu 2 , Mingwu Deng 3 , Pei Wang 1 , Guangyu Ji 1 , Mingsong Wang 1 , Chaohui Zhou 4 , Nicholas Thomas Blum 2 , Wenjie Zhang 3 , Huali Shi 4 , Nengqin Jia 4 , Xiansong Wang 1, 3 , Peng Huang 2
ACS Nano ( IF 15.8 ) Pub Date : 2021-11-11 , DOI: 10.1021/acsnano.1c06036 Mengting Yin 1 , Jiayingzi Wu 2 , Mingwu Deng 3 , Pei Wang 1 , Guangyu Ji 1 , Mingsong Wang 1 , Chaohui Zhou 4 , Nicholas Thomas Blum 2 , Wenjie Zhang 3 , Huali Shi 4 , Nengqin Jia 4 , Xiansong Wang 1, 3 , Peng Huang 2
Affiliation
|
Diabetic wound healing is one of the major challenges in the biomedical fields. The conventional single drug treatments have unsatisfactory efficacy, and the drug delivery effectiveness is restricted by the penetration depth. Herein, we develop a magnesium organic framework-based microneedle patch (denoted as MN-MOF-GO-Ag) that can realize transdermal delivery and combination therapy for diabetic wound healing. Multifunctional magnesium organic frameworks (Mg-MOFs) are mixed with poly(γ-glutamic acid) (γ-PGA) hydrogel and loaded into the tips of MN-MOF-GO-Ag, which slowly releases Mg2+ and gallic acid in the deep layer of the dermis. The released Mg2+ induces cell migration and endothelial tubulogenesis, while gallic acid, a reactive oxygen species-scavenger, promotes antioxidation. Besides, the backing layer of MN-MOF-GO-Ag is made of γ-PGA hydrogel and graphene oxide-silver nanocomposites (GO-Ag) which further enables excellent antibacterial effects for accelerating wound healing. The therapeutic effects of MN-MOF-GO-Ag on wound healing are demonstrated with the full-thickness cutaneous wounds of a diabetic mouse model. The significant improvement of wound healing is achieved for mice treated with MN-MOF-GO-Ag.
中文翻译：
用于加速糖尿病伤口愈合的多功能镁有机骨架微针贴片
糖尿病伤口愈合是生物医学领域的主要挑战之一。传统的单一药物治疗疗效不理想，药物递送效果受穿透深度限制。在此，我们开发了一种基于镁有机骨架的微针贴片（表示为 MN-MOF-GO-Ag），可以实现糖尿病伤口愈合的透皮给药和联合治疗。多功能镁有机骨架 (Mg-MOFs) 与聚（γ-谷氨酸）(γ-PGA) 水凝胶混合并加载到 MN-MOF-GO-Ag 的尖端，缓慢释放 Mg 2+和没食子酸真皮深层。释放的 Mg 2+诱导细胞迁移和内皮小管生成，而没食子酸是一种活性氧清除剂，可促进抗氧化。此外，MN-MOF-GO-Ag 的背衬层由 γ-PGA 水凝胶和氧化石墨烯-银纳米复合材料 (GO-Ag) 制成，进一步具有出色的抗菌效果，可加速伤口愈合。MN-MOF-GO-Ag 对伤口愈合的治疗效果通过糖尿病小鼠模型的全层皮肤伤口得到证明。用 MN-MOF-GO-Ag 处理的小鼠实现了伤口愈合的显着改善。
更新日期：2021-11-23
中文翻译：
用于加速糖尿病伤口愈合的多功能镁有机骨架微针贴片
糖尿病伤口愈合是生物医学领域的主要挑战之一。传统的单一药物治疗疗效不理想，药物递送效果受穿透深度限制。在此，我们开发了一种基于镁有机骨架的微针贴片（表示为 MN-MOF-GO-Ag），可以实现糖尿病伤口愈合的透皮给药和联合治疗。多功能镁有机骨架 (Mg-MOFs) 与聚（γ-谷氨酸）(γ-PGA) 水凝胶混合并加载到 MN-MOF-GO-Ag 的尖端，缓慢释放 Mg 2+和没食子酸真皮深层。释放的 Mg 2+诱导细胞迁移和内皮小管生成，而没食子酸是一种活性氧清除剂，可促进抗氧化。此外，MN-MOF-GO-Ag 的背衬层由 γ-PGA 水凝胶和氧化石墨烯-银纳米复合材料 (GO-Ag) 制成，进一步具有出色的抗菌效果，可加速伤口愈合。MN-MOF-GO-Ag 对伤口愈合的治疗效果通过糖尿病小鼠模型的全层皮肤伤口得到证明。用 MN-MOF-GO-Ag 处理的小鼠实现了伤口愈合的显着改善。
京公网安备 11010802027423号