血清甲状腺球蛋白和抗甲状腺球蛋白抗体对甲状腺癌患者甲状腺切除术后预后的价值,Diagnostics

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血清甲状腺球蛋白和抗甲状腺球蛋白抗体对甲状腺癌患者甲状腺切除术后预后的价值
Diagnostics ( IF 3.0 ) Pub Date : 2021-11-10 , DOI: 10.3390/diagnostics11112080
Hashem O Zahra ₁ , Gamal A Omran ₁ , Ahmed G Gewely ₂ , Ahmed Fathy Eldehn ₃ , Walied Abdo ₄ , Ehab Kotb Elmahallawy ₅ , Tarek M Okda ₁

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分化良好的甲状腺癌（WDTC）是一种恶性的头颈部肿瘤，发病率非常高。甲状腺切除的 WDTC 患者已被转诊至核医学进行放射性碘 (RAI) 消融治疗和/或诊断性全身成像的年度随访。血清甲状腺球蛋白 (TG) 和甲状腺球蛋白抗体 (TGAb) 是用于监测 WDTC 的生化肿瘤标志物。WDTC 患病率的全球上升正在增加需要终生监测持续性或复发性疾病的甲状腺切除患者的数量。本研究旨在确定甲状腺全切除术和 RAI 治疗后定义明确的甲状腺癌患者中最成功的预后因素，然后估计 TG 和 TGAb 的临界值。在这种情况下，共招募了100名受试者并分类如下：60名甲状腺癌患者接受了甲状腺全切术并成功进行了RAI治疗，而40名年龄、性别和社会经济地位相匹配的正常健康人构成了对照组。有趣的是，TG 水平在复发和非复发病例之间没有显着差异，但 TGAb 水平在复发和非复发病例之间存在显着差异。总体而言，TG 和 TGAb 被认为是甲状腺全切除术和 RAI 治疗后定义明确的甲状腺癌患者中最成功的预后因素。本研究还得出结论，TGAb 测定优于 TG 水平，截断值为 10 ng/mL。这些发现为甲状腺切除的 WDTC 患者的随访和终生监测提供了基线信息。需要进一步的研究来更大规模地探索更多关于甲状腺癌患者血清 TG 和 TGAb 的信息。

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Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy

Well-differentiated thyroid cancer (WDTC) is a malignant head and neck tumor with a very high incidence. Thyroidectomized WDTC patients have been referred to nuclear medicine for radioactive iodine (RAI) ablation therapy and/or annual follow-up with diagnostic whole-body imaging. Serum thyroglobulin (TG) and thyroglobulin antibodies (TGAb) are biochemical tumor markers used to monitor WDTC. A global rise in the prevalence of WDTC is increasing the number of thyroidectomized patients requiring lifelong monitoring for persistent or recurrent diseases. The present study aimed to identify the most successful prognostic factors in well-defined thyroid carcinoma patients following total thyroidectomy and RAI therapy, followed by an estimation of the cutoff value of TG and TGAb. In this context, a total of 100 subjects were recruited and classified as follows: 60 thyroid carcinoma patients underwent total thyroidectomy and successful RAI therapy, while 40 normal healthy individuals matched for age, sex, and socioeconomic status constituted the control group. Interestingly, the levels of TG did not differ significantly between the relapsed and non-relapsed cases, but the levels of TGAb differed significantly between the relapsed and non-relapsed cases. Collectively, TG and TGAb are considered the most successful prognostic factors in well-defined thyroid carcinoma patients after total thyroidectomy and RAI therapy. The present study also concluded that the TGAb determination was better than that of the TG level, with a cutoff value of 10 ng/mL. These findings provide baseline information for follow-up and lifelong monitoring of thyroidectomized WDTC patients. Further research is warranted to explore more about serum TG and TGAb in thyroid carcinoma patients on a larger scale.

更新日期：2021-11-10

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