Copper-Free Click Chemistry: Applications in Drug Delivery, Cell Tracking, and Tissue Engineering,Advanced Materials

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Copper-Free Click Chemistry: Applications in Drug Delivery, Cell Tracking, and Tissue Engineering
Advanced Materials ( IF 27.4 ) Pub Date : 2021-11-09 , DOI: 10.1002/adma.202107192
Hong Yeol Yoon ₁ , Donghyun Lee ₂ , Dong-Kwon Lim ₃ , Heebeom Koo ₂ , Kwangmeyung Kim _{1,

3}

Affiliation

Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or high pressure. However, copper-free click chemistry has been shown to have favorable reaction rates and orthogonality in water, buffer solutions, and physiological conditions without toxic catalysts. Strain-promoted azide-alkyne cycloaddition and inverse electron-demand Diels–Alder reactions are representative of copper-free click chemistry. Artificial chemical reactions via click chemistry can also be used outside of the laboratory in a controllable manner on live cell surfaces, in the cytosol, and in living bodies. Consequently, copper-free click chemistry has many features that are of interest in biomedical research, and various new materials and strategies for its use have been proposed. Herein, recent remarkable trials that have used copper-free click chemistry are described, focusing on their applications in molecular imaging and therapy. The research is categorized as nanoparticles for drug delivery, imaging agents for cell tracking, and hydrogels for tissue engineering, which are rapidly advancing fields based on click chemistry. The content is based primarily on the experience with click chemistry-based biomaterials over the last 10 years.

中文翻译：

无铜点击化学：在药物输送、细胞追踪和组织工程中的应用

传统上，有机化学反应需要有机溶剂、有毒催化剂、热量或高压。然而，无铜点击化学已被证明在没有有毒催化剂的情况下在水、缓冲溶液和生理条件下具有良好的反应速率和正交性。应变促进的叠氮化物-炔烃环加成和逆电子需求 Diels-Alder 反应是无铜点击化学的代表。通过点击化学的人工化学反应也可以在实验室外以可控的方式在活细胞表面、细胞质和活体中使用。因此，无铜点击化学具有许多生物医学研究感兴趣的特征，并且已经提出了各种新材料和使用策略。在此处，描述了最近使用无铜点击化学的显着试验，重点是它们在分子成像和治疗中的应用。该研究被归类为用于药物递送的纳米颗粒、用于细胞追踪的显像剂和用于组织工程的水凝胶，这些都是基于点击化学的快速发展领域。内容主要基于过去 10 年基于点击化学的生物材料的经验。

更新日期：2021-11-09

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